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Last reviewed on RxList: 5/11/2020

What is Aklief Cream?

Aklief Cream is a prescription medicine used on the skin (topical) to treat acne vulgaris in people 9 years of age and older.

What are the possible side effects of Aklief Cream?

Aklief Cream may cause serious side effects including:

  • Local skin irritation. Local skin reactions are common with Aklief Cream, are most likely to happen during the first 4 weeks of treatment and may decrease with continued use of Aklief Cream. Signs and symptoms of local skin reactions include:
    • redness
    • scaling
    • dryness
    • stinging or burning

To help reduce your risk of developing these local skin reactions, when you begin treatment with Aklief Cream, you should begin applying a moisturizer on your skin as often as needed.

Tell your healthcare provider if you develop symptoms of a local skin reaction. Your doctor may tell you to use Aklief Cream less often, or temporarily, or permanently stop your treatment with Aklief Cream.

The most common side effects of Aklief Cream include: itching and sunburn.

These are not all the possible side effects of Aklief Cream. For more information, ask your healthcare provider or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


AKLIEF Cream for topical administration contains 0.005% (50 mcg/g) trifarotene. Trifarotene is a terphenyl acid derivative and is a retinoid. The chemical name of trifarotene is 3”-tert-Butyl-4’-(2-hydroxy-ethoxy)-4”-pyrrolidin-1-yl-[1,1’,3’,1”]terphenyl-4­carboxylic acid. Trifarotene has the molecular formula of C29H33NO4, the molecular weight of 459.58, and the following structural formula:

AKLIEF® (trifarotene) Structural Formula - Illustration

Trifarotene is a white to off-white to slightly yellow powder with the melting point of 245°C. It is practically insoluble in water with pKa1 of 5.69 and pKa2 of 4.55.

AKLIEF (trifarotene) Cream 0.005% contains the following inactive ingredients: allantoin, copolymer of acrylamide and sodium acryloyldimethyltaurate, dispersion 40% in isohexadecane, cyclomethicone, 5% ethanol, medium-chain triglycerides, phenoxyethanol, propylene glycol, purified water.