Aklief vs. Amnesteem

Are Aklief and Amnesteem the Same Thing?

Aklief (trifarotene) Cream and Amnesteem (isotretinoin capsules) are retinoids used to treat acne vulgaris.

Amnesteem is used to treat severe recalcitrant nodular acne.

Aklief Cream is a topical preparation and Amnesteem is taken orally.

Side effects of Aklief Cream that are different from Amnesteem include application site reactions (such as irritation, itching, pain, redness, dryness, stinging/burning, discoloration, rash, swelling, and lesions), sunburn, acne, and allergic dermatitis.

Side effects of Amnesteem that are different from Aklief Cream include dry skin, chapped lips, dry eyes, and dry nose that may lead to nosebleeds.

Aklief Cream may interact with other drugs.

Amnesteem may interact with vitamin A, tetracycline antibiotics, hormonal contraceptives, St. John's wort, phenytoin, and corticosteroids.

What Are Possible Side Effects of Aklief?

Common side effects of Aklief include:

  • application site reactions such as:
    • irritation,
    • itching,
    • pain,
    • redness,
    • dryness,
    • stinging/burning,
    • discoloration,
    • rash,
    • swelling, and
    • lesions
  • sunburn,
  • acne, and
  • allergic dermatitis

What Are Possible Side Effects of Amnesteem?

Common side effects of Amnesteem include:

  • dry skin,
  • chapped lips,
  • dry eyes, and
  • dry nose that may lead to nosebleeds.

Tell your doctor if you have serious side effects of Amnesteem including:

What Is Aklief?

Aklief (trifarotene) Cream is a retinoid indicated for the topical treatment of acne vulgaris in patients 9 years of age and older.

What Is Amnesteem?

Amnesteem (isotretinoin capsules) is a retinoid indicated for the treatment of severe recalcitrant nodular acne.


Skin Health: 15 Tips for Clear Skin See Slideshow

What Drugs Interact With Aklief?

Aklief may interact with other drugs. Tell your doctor all medications and supplements you use.

What Drugs Interact With Amnesteem?

Amnesteem may interact with steroids or tetracycline antibiotics.

Amnesteem may also interact with vitamin A, hormonal contraceptives, St. John's wort, and phenytoin.

How Should Aklief Be Taken?

The dose of Aklief Cream is a thin layer applied to the affected areas of the face and/or trunk once a day, in the evening, on clean and dry skin.

How Should Amnesteem Be Taken?

The recommended dosage range for Amnesteem is 0.5 to 1 mg/kg/day given in two divided doses with food for 15 to 20 weeks.


Acne is the result of an allergy. See Answer

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Galderma. Aklief Product Information.


Mylan/Dailymed. Amnesteem Product Information.


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