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Last reviewed on RxList: 3/2/2017
Alcaine Side Effects Center

Last reviewed on RxList 11/30/2016

Alcaine (proparacaine hydrochloride 0.5%) is a topical anesthetic for the eyes used during eye surgeries and procedures. Alcaine is available in generic form. Common side effects of Alcaine include:

  • eye irritation,
  • stinging,
  • burning,
  • redness,
  • tearing, or
  • increased blinking.

The recommended dosage of Alcaine is 1 or 2 drops prior to having surgery or procedure and 1 drop every 5 or 10 minutes for 5 to 7 doses for cataract extraction. Rinse your eyes with sterile distilled water before using Alcaine. Avoid rubbing or touching your eyes until Alcaine has worn off. Alcaine may interact with other drugs. Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plant to become pregnant before treatment with Alcaine; it is unknown if it would affect a fetus. It is unknown if Alcaine passes into breast milk. Consult your doctor before breastfeeding.

Our Alcaine (proparacaine hydrochloride 0.5%) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Alcaine Professional Information


Pupillary dilatation or cycloplegic effects have rarely been observed with proparacaine hydrochloride. The drug appears to be safe for use in patients sensitive to other local anesthetics, but local or systemic sensitivity occasionally occurs. Instillation of proparacaine in the eye at recommended concentration and dosage usually produces little or no initial irritation, stinging, burning, conjunctival redness, lacrimation or increased winking. However, some local irritation and stinging may occur several hours after the instillation. Rarely, a severe immediate-type, apparently hyperallergic corneal reaction may occur which includes acute, intense and diffuse epithelial keratitis; a gray, ground-glass appearance; sloughing of large areas of necrotic epithelium; corneal filaments and, sometimes, iritis with descemetitis. Allergic contact dermatitis with drying and fissuring of the fingertips has been reported. Softening and erosion of the corneal epithelium and conjunctival congestion and hemorrhage have been reported.

Read the entire FDA prescribing information for Alcaine (Proparacaine Hydrochloride Ophthalmic Solution)

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© Alcaine Patient Information is supplied by Cerner Multum, Inc. and Alcaine Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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