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Aldactazide

Last reviewed on RxList: 10/27/2017
Aldactazide Side Effects Center

Last reviewed on RxList 10/27/2017

Aldactazide (spironolactone and hydrochlorothiazide) is a combination of two diuretics used to treat fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or a kidney disorder called nephrotic syndrome. Aldactazide also treats high blood pressure (hypertension). Aldactazide is available in generic form. Common side effects of Aldactazide include:

Aldactazide may cause a loss of too much body water (dehydration) and salt/minerals. Tell your doctor if you have serious symptoms of dehydration or mineral loss including very dry mouth, extreme thirst, muscle cramps, weakness, vomiting, fast heartbeat, severe dizziness, confusion, unusual decrease in the amount of urine, fainting, or seizures. Tell your doctor right away if you have any serious side effects of Aldactazide including:

  • joint pain,
  • breast pain,
  • breast enlargement in men (gynecomastia),
  • easy bruising or bleeding,
  • unusual change in the amount of urine (not including the normal increase in urine when you first start this drug),
  • yellowing eyes or skin,
  • dark urine,
  • severe stomach or abdominal pain,
  • decrease in vision, or
  • eye pain.

The usual maintenance dose of Aldactazide is 100 mg each of spironolactone and hydrochlorothiazide daily, given in a single dose or in divided doses, but may range from 25 mg to 200 mg of each component daily depending on patient response. Aldactazide may interact with medications that cause light-headedness (e.g., cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety), other blood pressure medications, lithium, digoxin, steroids, blood thinners, insulin or oral diabetes medicines, ACE inhibitors, indomethacin, or other NSAIDs (nonsteroidal anti-inflammatory drugs). Tell your doctor all medications you use. During pregnancy, Aldactazide should be used only when prescribed. Spironolactone and hydrochlorothiazide both pass into breast milk but are unlikely to harm a nursing infant. Consult your doctor before breastfeeding.

Our Aldactazide (spironolactone and hydrochlorothiazide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

In the U.S., 1 in every 4 deaths is caused by heart disease. See Answer
Aldactazide Consumer Information

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).

Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you began using hydrochlorothiazide and spironolactone.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;
  • sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, easy bruising, unusual bleeding, purple or red pinpoint spots under your skin;
  • eye pain, vision problems;
  • breast swelling and tenderness;
  • high potassium--slow heart rate, weak pulse, muscle weakness, tingly feeling;
  • low potassium--confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling; or
  • low sodium--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.

Common side effects may include:

  • drowsiness, dizziness, lack of energy;
  • leg cramps; or
  • itching, hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Aldactazide (Spironolactone and Hydrochlorothiazide)

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Aldactazide Professional Information

SIDE EFFECTS

The following adverse reactions have been reported and, within each category (body system), are listed in order of decreasing severity.

Hydrochlorothiazide

Body as a whole: Weakness.

Cardiovascular: Hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics, or antihypertensive drugs).

Digestive: Pancreatitis, jaundice (intrahepatic cholestatic jaundice), diarrhea, vomiting, sialoadenitis, cramping, constipation, gastric irritation, nausea, anorexia.

Eye Disorders: acute myopia and acute angle closure glaucoma (see WARNINGS). Hematologic: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia.

Hypersensitivity: Anaphylactic reactions, necrotizing angitis (vasculitis and cutaneous vasculitis), respiratory distress including pneumonitis and pulmonary edema, photosensitivity, fever, urticaria, rash, purpura.

Metabolic: Electrolyte imbalance (see PRECAUTIONS), hyperglycemia, glycosuria, hyperuricemia.

Musculoskeletal: Muscle spasm.

Nervous system/psychiatric: Vertigo, paresthesias, dizziness, headache, restlessness.

Renal: Renal failure, renal dysfunction, interstitial nephritis (see WARNINGS).

Skin: Erythema multiforme, pruritus.

Special senses: Transient blurred vision, xanthopsia.

Spironolactone

Digestive: Gastric bleeding, ulceration, gastritis, diarrhea and cramping, nausea, vomiting.

Reproductive: Gynecomastia (see PRECAUTIONS), inability to achieve or maintain erection, irregular menses or amenorrhea, postmenopausal bleeding, breast pain. Carcinoma of the breast has been reported in patients taking spironolactone but a cause and effect relationship has not been established.

Hematologic: Leukopenia (including agranulocytosis), thrombocytopenia.

Hypersensitivity: Fever, urticaria, maculopapular or erythematous cutaneous eruptions, anaphylactic reactions, vasculitis.

Metabolism: Hyperkalemia, electrolyte disturbances (see WARNINGS and PRECAUTIONS).

Musculoskeletal: Leg cramps.

Nervous system/psychiatric: Lethargy, mental confusion, ataxia, dizziness, headache, drowsiness.

Liver/biliary: A very few cases of mixed cholestatic/hepatocellular toxicity, with one reported fatality, have been reported with spironolactone administration.

Renal: Renal dysfunction (including renal failure).

Skin: Stevens-Johnson Syndrome (SJS), toxic epidermal necrolysis (TEN), drug rash with eosinophilia and systemic symptoms (DRESS), alopecia, pruritus.

Read the entire FDA prescribing information for Aldactazide (Spironolactone and Hydrochlorothiazide)

SLIDESHOW

Heart Disease: Symptoms, Signs, and Causes See Slideshow
Related Resources for Aldactazide

Read the Aldactazide User Reviews »

© Aldactazide Patient Information is supplied by Cerner Multum, Inc. and Aldactazide Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

QUESTION

In the U.S., 1 in every 4 deaths is caused by heart disease. See Answer

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