Aldoril Side Effects Center

Last updated on RxList: 1/19/2023
Aldoril Side Effects Center

What Is Aldoril?

Aldoril (methyldopa and hydrochlorothiazide) is a combination antihypertensive and diuretic used to treat high blood pressure (hypertension). The brand name Aldoril is discontinued, but generic versions may be available.

What Are Side Effects of Aldoril?

Aldoril may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • pale or yellow skin,
  • dark colored urine,
  • fever,
  • confusion,
  • weakness,
  • lightheadedness,
  • severe pain in your upper stomach spreading to your back,
  • nausea,
  • vomiting,
  • fast heart rate,
  • shortness of breath,
  • swelling,
  • rapid weight gain,
  • uncontrolled muscle movements,
  • unusual thoughts or behavior,
  • numbness,
  • tingling,
  • weakness,
  • chest pain,
  • easy bruising,
  • unusual bleeding,
  • dry mouth,
  • leg cramps,
  • increased thirst or urination,
  • mood changes,
  • constipation,
  • bone pain,
  • muscle pain or weakness,
  • lack of energy,
  • irregular heartbeats,
  • fluttering in your chest,
  • little or no urine,
  • sore throat,
  • burning in your eyes, and
  • skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling
  • Get medical help right away, if you have any of the symptoms listed above.
  • The most common side effects of Aldoril include:
  • abnormal liver function tests,
  • headache,
  • drowsiness,
  • weakness,
  • dizziness,
  • swelling,
  • weight gain,
  • muscle or joint pain,
  • muscle spasms, and
  • stuffy nose

Tell the doctor if you have any side effect that bothers you or that does not go away.

Common side effects of Aldoril include dizziness, lightheadedness, drowsiness, headache, stuffy nose, and weakness as your body adjusts to the medication. Other side effects of Aldoril include:

  •  stomach cramps
  • diarrhea
  • constipation
  • depression
  • trouble concentrating
  • joint pain
  • muscle pain
  • restlessness
  • soreness or black discoloration of your tongue
  • blurred vision
  • impotence, or
  • loss of interest in sex

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheadedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Aldoril

The usual starting dosage is one tablet of Aldoril 15 two or three times a day or one tablet of Aldoril 25 two times a day.

What Drugs, Substances, or Supplements Interact with Aldoril?

Aldoril may interact with cholestyramine, colestipol, digoxin, insulin or oral diabetes medications, lithium, barbiturates, medicines that contain iron, muscle relaxers, narcotics, steroids, other blood pressure medications, or nonsteroidal anti-inflammatory drugs (NSAIDs). Tell your doctor all medications and supplements you use.

Aldoril During Pregnancy or Breastfeeding

During pregnancy, Aldoril should be used only when prescribed. This drug passes into breast milk but is unlikely to harm a nursing infant. Consult your doctor before breastfeeding.

Additional Information

Our Aldoril (methyldopa and hydrochlorothiazide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

SLIDESHOW

How to Lower Blood Pressure: Exercise Tips See Slideshow
Aldoril Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • pale or yellowed skin, dark colored urine, fever, confusion or weakness;
  • a light-headed feeling, like you might pass out;
  • severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;
  • shortness of breath (even with mild exertion), swelling, rapid weight gain;
  • uncontrolled muscle movements;
  • unusual thoughts or behavior;
  • numbness, tingling, weakness;
  • chest pain;
  • easy bruising, unusual bleeding;
  • signs of an electrolyte imbalance--dry mouth, leg cramps, increased thirst or urination, mood changes, confusion, numbness or tingling, constipation, vomiting, bone pain, muscle pain or weakness, lack of energy, irregular heartbeats, fluttering in your chest, little or no urine; or
  • severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Common side effects may include:

  • abnormal liver function tests;
  • headache, drowsiness, weakness;
  • dizziness;
  • swelling, weight gain;
  • muscle or joint pain, muscle spasms; or
  • stuffy nose.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

Salt and sodium are the same. See Answer
Aldoril Professional Information

SIDE EFFECTS

The following adverse reactions have been reported and, within each category, are listed in order of decreasing severity.

Methyldopa

Sedation, usually transient, may occur during the initial period of therapy or whenever the dose is increased. Headache, asthenia, or weakness may be noted as early and transient symptoms. However, significant adverse effects due to methyldopa have been infrequent and this agent usually is well tolerated.

Cardiovascular: Aggravation of angina pectoris, congestive heart failure, prolonged carotid sinus hypersensitivity, orthostatic hypotension (decrease daily dosage), edema or weight gain, bradycardia.

Digestive: Pancreatitis, colitis, vomiting, diarrhea, sialadenitis, sore or “black” tongue, nausea, constipation, distention, flatus, dryness of mouth.

Endocrine: Hyperprolactinemia.

Hematologic: Bone marrow depression, leukopenia, granulocytopenia, thrombocytopenia, hemolytic anemia; positive tests for antinuclear antibody, LE cells, and rheumatoid factor, positive Coombs test.

Hepatic: Liver disorders including hepatitis, jaundice, abnormal liver function tests (see WARNINGS).

Hypersensitivity: Myocarditis, pericarditis, vasculitis, lupus-like syndrome, drug-related fever, eosinophilia.

Nervous System/Psychiatric: Parkinsonism, Bell's palsy, decreased mental acuity, involuntary choreoathetotic movements, symptoms of cerebrovascular insufficiency, psychic disturbances including nightmares and reversible mild psychoses or depression, headache, sedation, asthenia or weakness, dizziness, lightheadedness, paresthesias.

Metabolic: Rise in BUN.

Musculoskeletal: Arthralgia, with or without joint swelling; myalgia.

Respiratory: Nasal stuffiness.

Skin: Toxic epidermal necrolysis, rash.

Urogenital: Amenorrhea, breast enlargement, gynecomastia, lactation, impotence, decreased libido.

Hydrochlorothiazide

Body as a Whole: Weakness.

Cardiovascular: Hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs).

Digestive: Pancreatitis, jaundice (intrahepatic cholestatic jaundice), diarrhea, vomiting, sialadenitis, cramping, constipation, gastric irritation, nausea, anorexia.

Hematologic: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia.

Hypersensitivity: Anaphylactic reactions, necrotizing angiitis (vasculitis and cutaneous vasculitis), respiratory distress including pneumonitis and pulmonary edema, photosensitivity, fever, urticaria, rash, purpura.

Metabolic:Electrolyte imbalance (see PRECAUTIONS), hyperglycemia, glycosuria, hyperuricemia.

Musculoskeletal:Muscle spasm.

Nervous System/Psychiatric: Vertigo, paresthesias, dizziness, headache, restlessness.

Renal: Renal failure, renal dysfunction, interstitial nephritis. (See WARNINGS.)

Skin: Erythema multiforme including Stevens-Johnson syndrome, exfoliative dermatitis including toxic epidermal necrolysis, alopecia.

Special Senses: Transient blurred vision, xanthopsia.

Urogenital: Impotence.

Read the entire FDA prescribing information for Aldoril (Methyldopa-Hydrochlorothiazide)

© Aldoril Patient Information is supplied by Cerner Multum, Inc. and Aldoril Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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