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Aloxi Capsules

Last reviewed on RxList: 4/14/2020
Aloxi Capsules Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Are Aloxi Capsules?

Aloxi (palonosetron HCl) Capsules is an antiemetic and antinauseant drug used to prevent nausea and vomiting that may be caused by medicine to treat cancer (chemotherapy). The brand name Aloxi Capsules are discontinued, but generic versions may be available. Common side effects of Aloxi (palonosetron HCl) Capsules include headache, constipation, or tired feeling.

What Are Side Effects of Aloxi Capsules?

Uncommon side effects of Aloxi (palonosetron HCl) Capsules include:

Dosage for Aloxi Capsules

Dosage for Aloxi

Dosage of Aloxi for adults is a single 0.25 mg I.V. dose administered over 30 seconds, given approximately 30 minutes before the start of chemotherapy.

What Drugs, Substances, or Supplements Interact with Aloxi Capsules?

Aloxi may interact with diuretics (water pills), or heart rhythm medication.

Aloxi Capsules During Pregnancy and Breastfeeding

Tell your doctor all medications you use. Aloxi should be used only when prescribed during pregnancy. It is unknown if this medication passes into breast milk or may harm a nursing infant. Consult your doctor before breastfeeding.

Additional Information

Our Aloxi (palonosetron hydrochloride) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Aloxi Capsules Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; chest pain, difficult breathing; swelling of your face, lips, tongue, or throat.

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common side effects may include:

  • nausea, vomiting;
  • constipation;
  • slow heartbeats; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Aloxi Capsules (Palonosetron HCl Capsules)

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Aloxi Capsules Professional Information

SIDE EFFECTS

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. In clinical trials for the prevention of nausea and vomiting induced by moderately emetogenic chemotherapy, 693 adult patients received oral palonosetron in doses ranging from 0.25 mg to 0.75 mg. Following is a listing of drug related adverse reactions reported by ≥ 2% of patients from two clinical trials.

Table 1: Adverse Reactions ≥ 2% from Chemotherapy-Induced Nausea and Vomiting Studies

Event 0.25 mg
(N=157)
0.5 mg
(N=161)
0.75 mg
(N=375)
0.25 mg I.V.
(N=163)
Headache 6 (3.8%) 6 (3.7%) 21 (5.6%) 14 (8.6%)
Constipation 1 (0.6%) 1 (0.6%) 9 (2.4%) 5 (3.1%)

The infrequently reported adverse reactions listed below, assessed by investigators as treatment-related or causality unknown/missing, occurred following administration of ALOXI (palonosetron hcl capsules) Capsules to adult patients receiving concomitant cancer chemotherapy. Of these adverse events, fatigue (incidence 1%), was the only adverse event reported at an incidence of ≥ 1%. In general, adverse reactions were similar between oral and I.V. formulations.

Blood and Lymphatic System: <1%: anemia.

Cardiovascular: <1%: hypertension, transient arrhythmia, first degree atrioventricular block, second degree atrioventricular block, QTc prolongation.

Hearing and Labyrinth: <1%: motion sickness.

Eye: <1%: eye swelling.

Gastrointestinal System: <1%: gastritis, nausea, vomiting.

General: 1%: fatigue, <1%: chills, pyrexia.

Infections: <1%: sinusitis.

Liver: <1%: transient, asymptomatic increases in bilirubin.

Nutrition: <1%: anorexia.

Musculoskeletal: <1%: joint stiffness, myalgia, pain in extremity.

Nervous System: <1%: postural dizziness, dysgeusia.

Psychiatric: <1%: insomnia.

Respiratory System: <1%: dyspnea, epistaxis.

Skin: <1%: generalized pruritus, erythema, alopecia.

Very rare cases (<1/10,000) of hypersensitivity reactions have been reported for I.V. ALOXI (palonosetron hcl capsules) from post-marketing experience.

Read the entire FDA prescribing information for Aloxi Capsules (Palonosetron HCl Capsules)

Related Resources for Aloxi Capsules

Related Drugs

© Aloxi Capsules Patient Information is supplied by Cerner Multum, Inc. and Aloxi Capsules Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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