Last updated on RxList: 1/28/2021
Altreno Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Altreno?

Altreno (tretinoin) Lotion is a retinoid indicated for the topical treatment of acne vulgaris in patients 9 years of age and older.

What Are Side Effects of Altreno?

Common side effects of Altreno include:

  • skin dryness,
  • pain,
  • redness,
  • irritation,
  • peeling,
  • itching,
  • burning,
  • stinging, and
  • discoloration (all at the application site)

Dosage for Altreno

Apply a dose of a thin layer of Altreno to affected areas once daily. Avoid eyes, mouth, paranasal creases, and mucous membranes.

What Drugs, Substances, or Supplements Interact with Altreno?

Altreno may interact with other drugs. Tell your doctor all medications and supplements you use.

Altreno During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using Altreno; it is unknown how it would affect a fetus. It is unknown if Altreno passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Altreno (tretinoin) Lotion, for Topical Use Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Skin Health: 15 Tips for Clear Skin See Slideshow
Altreno Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe burning, stinging, or irritation of treated skin;
  • severe skin dryness; or
  • severe redness, swelling, blistering, peeling, or crusting.

Your skin may be more sensitive to weather extremes such as cold and wind while using this medicine.

Common side effects may include:

  • skin pain, redness, burning, itching, or irritation;
  • sore throat;
  • mild warmth or stinging where the medicine was applied; or
  • changes in color of treated skin.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Altreno (Tretinoin Lotion)


Acne is the result of an allergy. See Answer
Altreno Professional Information


Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in clinical practice.

In 2 randomized, double-blind, vehicle-controlled trials, subjects age 9 years and older applied ALTRENO or vehicle once daily for 12 weeks. The majority of subjects were White (74%) and female (55%). Approximately 47% were Hispanic/Latino and 45% were younger than 18 years of age. Adverse reactions reported by ≥1% of subjects treated with ALTRENO and more frequently than vehicle are summarized in Table 1.

Table 1: Adverse Reactions Reported by ≥1% of Subjects Treated with ALTRENO and More Frequently than Vehicle

Adverse Reactions
n (%)
Application site dryness 29 (4) 1 (<1)
Application site pain1 25 (3) 3 (<1)
Application site erythema 12 (2) 1 (<1)
Application site irritation 7 (1) 1 (<1)
Application site exfoliation 6 (1) 3 (<1)
1Application site pain defined as application site stinging, burning or pain.

Skin irritation was evaluated by active assessment of erythema, scaling, hypopigmentation, hyperpigmentation, itching, burning and stinging. The percentage of subjects who were assessed to have these signs and symptoms at any post baseline visit are summarized in Table 2.

Table 2: Application Site Tolerability Reactions at Any Post Baseline Visit

N=760 Mild/Mod/Severe
N=782 Mild/Mod/Severe
Erythema 51% 44%
Scaling 49% 30%
Hypopigmentation 12% 10%
Hyperpigmentation 35% 35%
Itching 35% 28%
Burning 30% 14%
Stinging 21% 8%

Read the entire FDA prescribing information for Altreno (Tretinoin Lotion)

© Altreno Patient Information is supplied by Cerner Multum, Inc. and Altreno Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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