Aluminum Hydroxide/Magnesium Hydroxide/Simethicone

Reviewed on 4/4/2022

What Is Aluminum Hydroxide/Magnesium Hydroxide/Simethicone and How Does It Work?

Aluminum Hydroxide/Magnesium Hydroxide/Simethicone is an over-the-counter medication used for relieving dyspepsia and abdominal bloating.

  • Aluminum Hydroxide/Magnesium Hydroxide/Simethicone is available under the following different brand names: Mylanta, Mygel, DiGel, Gelusil, Rulox

What Are Dosages of Aluminum Hydroxide/Magnesium Hydroxide/Simethicone?

Adult dosage


  • (200mg/200mg/20mg)/5mL
  • (400mg/400mg/40mg)/5mL


  • (225mg/200mg/25mg)/5mL

Tablet, chewable

  • 200mg/200mg/25mg (Gelusil)

Dyspepsia, Abdominal Bloating

Adult dosage

  • 10-20 mL orally every 4-6 hours taken 1 hour before or 3 hours after meals, OR
  • Chew 2-4 tablets every 4-6 hours; not to exceed 12 tablets/24 hours

Dosage Considerations – Should be Given as Follows: 

  • See “Dosages”

What Are Side Effects Associated with Using Aluminum Hydroxide/Magnesium Hydroxide/Simethicone?

Common side effects of Aluminum Hydroxide/Magnesium Hydroxide/Simethicone include:

  • black/tarry stools,
  • mental/mood changes (e.g., confusion, deep sleep),
  • pain with urination,
  • stomach/abdominal pain, and
  • vomit that looks like coffee grounds.

Serious side effects of Aluminum Hydroxide/Magnesium Hydroxide/Simethicone include:

  • nausea,
  • vomiting,
  • rebound hyperacidity,
  • aluminum-intoxication,
  • low blood phosphates (hypophosphatemia),
  • chalky taste,
  • constipation (this could lead to hemorrhoids or bowel obstruction),
  • fecal impaction,
  • stomach cramps,
  • milk-alkali syndrome, and
  • softening of the bones.

Rare side effects of Aluminum Hydroxide/Magnesium Hydroxide/Simethicone include:

  • none 
This is not a complete list of side effects and other serious side effects or health problems that may occur as a result of the use of this drug. Call your doctor for medical advice about serious side effects or adverse reactions. You may report side effects or health problems to FDA at 1-800-FDA-1088.

What Other Drugs Interact with Aluminum Hydroxide/Magnesium Hydroxide/Simethicone?

If your medical doctor is using this medicine to treat your pain, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider, or pharmacist first.

  • Aluminum Hydroxide/Magnesium Hydroxide/Simethicone has severe interactions with the following drug:
    • pazopanib
    • raltegravir
  • Aluminum Hydroxide/Magnesium Hydroxide/Simethicone has serious interactions with the following drugs:
  • Aluminum Hydroxide/Magnesium Hydroxide/Simethicone has moderate interactions with at least 132 other drugs.
  • Aluminum Hydroxide/Magnesium Hydroxide/Simethicone has minor interactions with at least 59 other drugs.

This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you and share this information with your doctor and pharmacist. Check with your health care professional or doctor for additional medical advice, or if you have health questions, concerns.

What Are Warnings and Precautions for Aluminum Hydroxide/Magnesium Hydroxide/Simethicone?


  • Hypersensitivity to any component of the formulation

Effects of drug abuse

  • None

Short-Term Effects

  • See “What Are Side Effects Associated with Using Aluminum Hydroxide/Magnesium Hydroxide/Simethicone?”

Long-Term Effects

  • See “What Are Side Effects Associated with Using Aluminum Hydroxide/Magnesium Hydroxide/Simethicone?”


  • Caution in renal failure
  • May increase or decrease rate &/or degree of absorption of concomitantly administered oral drugs by changing GI transit time or by binding the drug
  • Mg-restricted diet
  • Similar Trade Names may have different compositions
  • Do not use combination products for hyperphosphatemia

Pregnancy and Lactation

  • Use with caution if the benefits outweigh the risk during pregnancy
  • Lactation
    • Excretion in milk is unknown
Medscape. Aluminum Hydroxide/Magnesium Hydroxide/Simethicone.

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