Last updated on RxList: 1/7/2021
Alupent Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Alupent?

Alupent (metaproterenol sulfate) Aerosol is a bronchodilator used to treat conditions such as asthma, bronchitis, and emphysema. The brand name Alupent is discontinued, but generic versions may be available.

What Are Side Effects of Alupent?

Common side effects of Alupent (metaproterenol sulfate) include:

Tell your doctor if you experience serious side effects of Alupent including:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives), or
  • chest pains or an irregular heart beat.

Dosage for Alupent

The usual single dose of Alupent is two to three inhalations.

What Drugs, Substances, or Supplements Interact with Alupent?

Alupent may interact with beta-blockers, antidepressants, monoamine oxidase inhibitors (MAOIs), other inhaled or oral bronchodilators, caffeine, diet pills, or decongestants. Tell your doctor all medications and supplements you use.

Alupent During Pregnancy and Breastfeeding

It is unknown if Alupent will be harmful to a fetus. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Alupent (metaproterenol sulfate) Aerosol Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What Is Asthma? Symptoms, Causes, and Treatments See Slideshow
Alupent Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • chest pain, fast heart rate;
  • pounding heartbeats or fluttering in your chest;
  • a light-headed feeling, like you might pass out;
  • tremors; or
  • worsening or no improvement in your symptoms.

Common side effects may include:

  • nervousness;
  • headache;
  • dizziness, drowsiness;
  • nausea, diarrhea, upset stomach, dry mouth;
  • tired feeling; or
  • sleep problem (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Alupent (Metaproterenol Sulfate)


Asthma is a chronic respiratory disease. See Answer
Alupent Professional Information


Adverse reactions are similar to those noted with other sympathomimetic agents. The most frequent adverse reaction to Alupent( (metaproterenol sulfate USP) administered by metered-dose inhaler among 251 patients in 90-day controlled clinical trials was nervousness. This was reported in 6.8% of patients. Less frequent adverse experiences, occurring in 1-4% of patients were headache, dizziness, palpitations, gastrointestinal distress, tremor, throat irritation, nausea, vomiting, cough and asthma exacerbation. Tachycardia occurred in less than 1% of patients.

Read the entire FDA prescribing information for Alupent (Metaproterenol Sulfate)

© Alupent Patient Information is supplied by Cerner Multum, Inc. and Alupent Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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