Amerge Side Effects Center

Last updated on RxList: 12/15/2020
Amerge Side Effects Center

What Is Amerge?

Amerge (naratriptan) is a headache medicine used to treat migraine headaches. Amerge will only treat a headache that has already begun. Amerge will not prevent headaches or reduce the number of attacks. Amerge is available in generic form.

What Are Side Effects of Amerge?

Common side effects of Amerge include:

  • flushing,
  • sensations of tingling/numbness/prickling/heat/warmth under your skin,
  • weakness,
  • drowsiness,
  • tired feeling,
  • dizziness, or
  • pressure or heavy feeling in any part of your body

Dosage for Amerge

The adult dose of Amerge is 1 mg or 2.5 mg tablets taken with fluid. The dose may be repeated once after 4 hours, for a maximum dose of 5 mg in a 24-hour period.

What Drugs, Substances, or Supplements Interact with Amerge?

Amerge may interact with other migraine headache medicines, or antidepressants. Tell your doctor all medications you use.

Amerge During Pregnancy and Breastfeeding

Amerge should be used only when prescribed during pregnancy. It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Additional Information

Our Amerge (naratriptan) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Amerge Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using naratriptan and call your doctor at once if you have:

  • fast or pounding heartbeats;
  • numbness or tingling and a pale or blue-colored appearance in your fingers or toes;
  • pain or heavy feeling in your legs, hip pain, burning pain in your feet;
  • sudden and severe stomach pain, bloody diarrhea, constipation, fever, weight loss;
  • dangerously high blood pressure--severe headache, blurred vision, pounding in your neck or ears, nosebleed, anxiety, confusion, severe chest pain, shortness of breath, irregular heartbeats, seizure;
  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
  • high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting; or
  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech, problems with vision or balance.

Common side effects may include:

  • dizziness, drowsiness;
  • feeling weak or tired;
  • numbness or tingling;
  • flushing (warmth, redness, or tingly feeling);
  • nausea; or
  • pain or tightness in your jaw, neck, or throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Amerge Professional Information


The following adverse reactions are discussed in more detail in other sections of the prescribing information:

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.

In a long-term open-label trial where patients were allowed to treat multiple migraine attacks for up to 1 year, 15 patients (3.6%) discontinued treatment due to adverse reactions.

In controlled clinical trials, the most common adverse reactions were paresthesias, dizziness, drowsiness, malaise/fatigue, and throat/neck symptoms, which occurred at a rate of 2% and at least 2 times placebo rate.

Table 1 lists the adverse reactions that occurred in 5 placebo-controlled clinical trials of approximately 1,752 exposures to placebo and AMERGE in adult patients with migraine. Only reactions that occurred at a frequency of 2% or more in groups treated with AMERGE 2.5 mg and that occurred at a frequency greater than the placebo group in the 5 pooled trials are included in Table 1.

Table 1: Adverse Reactions Reported by at Least 2% of Patients Treated with AMERGE and at a Frequency Greater than Placebo

Adverse Reaction Percent of Patients Reporting
(n = 627)
AMERGE 2.5 mg
(n = 627)
(n = 498)
Atypical sensation 2 4 1
  Paresthesias (all types) 1 2 < 1
Gastrointestinal 6 7 5
  Nausea 4 5 4
Neurological 4 7 3
  Dizziness 1 2 1
  Drowsiness  1 2 < 1
  Malaise/fatigue 2 2 1
Pain and pressure sensation 2 4 2
  Throat/neck symptoms 1 2 1

The incidence of adverse reactions in controlled clinical trials was not affected by age or weight of the patients, duration of headache prior to treatment, presence of aura, use of prophylactic medications, or tobacco use. There were insufficient data to assess the impact of race on the incidence of adverse reactions.

Read the entire FDA prescribing information for Amerge (Naratriptan)

© Amerge Patient Information is supplied by Cerner Multum, Inc. and Amerge Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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