Amerge vs. Relpax

Reviewed on 5/11/2020

Are Amerge and Relpax the Same Thing?

Amerge (naratriptan) and Relpax (eletriptan hydrobromide) are headache medicines ("triptans") used to treat migraine headaches.

Amerge and Relpax will only treat a headache that has already begun. Amerge and Relpax will not prevent headaches or reduce the number of attacks.

Side effects of Amerge and Relpax that are similar include flushing (warmth, redness, or tingling under your skin), sensations of tingling/numbness/prickling/heat/warmth under your skin, weakness, drowsiness, dizziness, and pressure or heavy feeling in any part of your body.

Side effects of Amerge that are different from Relpax include tired feeling.

Side effects of Relpax that are different from Amerge include mild headache (not a migraine), nausea, upset stomach, stomach pain or cramps, and dry mouth.

Both Amerge and Relpax may interact with other migraine headache medicines, antidepressants, medicines to treat psychiatric disorders, narcotics (opioids), and medicines to prevent nausea and vomiting. Relpax may also interact with nefazodone, azole antifungals, antibiotics, protease inhibitors, St. John's wort, antihistamines, anti-seizure drugs, medicines for sleep or anxiety, and muscle relaxants.

What Are Possible Side Effects of Amerge?

Common side effects of Amerge include:

  • flushing,
  • sensations of tingling/numbness/prickling/heat/warmth under your skin,
  • weakness,
  • drowsiness,
  • tired feeling,
  • dizziness, or
  • pressure or heavy feeling in any part of your body

What Are Possible Side Effects of Relpax?

Common side effects of Relpax include:

  • mild headache (not a migraine),
  • tingling/numbness,
  • nausea,
  • upset stomach,
  • stomach pain or cramps,
  • weakness,
  • drowsiness,
  • dizziness,
  • pressure or heavy feeling in any part of your body,
  • dry mouth, or
  • flushing (warmth, redness, or tingling under your skin).

Tell your doctor if you have serious side effects of Relpax including:

  • blue fingers/toes/nails, or
  • cold hands or feet.

SLIDESHOW

16 Surprising Headache Triggers and Tips for Pain Relief See Slideshow

What is Amerge?

Amerge (naratriptan) is a headache medicine used to treat migraine headaches. Amerge will only treat a headache that has already begun. Amerge will not prevent headaches or reduce the number of attacks. Amerge is available in generic form.

What is Relpax?

Relpax (eletriptan hydrobromide) is a selective serotonin receptor agonist used to treat >migraine headaches. Relpax will only treat a headache that has already begun. Relpax will not prevent headaches or reduce the number of attacks.

What Drugs Interact With Amerge?

Amerge may interact with other migraine headache medicines, or antidepressants. Tell your doctor all medications you use. Amerge should be used only when prescribed during pregnancy. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

What Drugs Interact With Relpax?

Relpax should not be used with sibutramine because a very serious interaction may occur. Relpax should not be used within 72 hours of use of drugs affecting liver enzymes that remove eletriptan from your body such as nefazodone, azole antifungals, antibiotics, and protease inhibitors. Relpax should not be used within 24 hours of use of ergot-type drugs or other migraine drugs because of serious interactions. Antidepressants, St. John's wort, antihistamines, anti-seizure drugs, medicine for sleep or anxiety, muscle relaxants, narcotic pain relievers, and psychiatric medicines may all adversely interact with this drug. Discuss all medications you are taking with your doctor.

How Should Amerge be Taken?

The dosage of Amerge is 25 mg four times a day.

How Should Relpax be Taken?

A single dose of 20 mg or 40 mg is effective for the acute treatment of migraine in adults. After taking Relpax, you must wait 2 hours before taking another dose.
Disclaimer

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

References
GSK. Amerge Prescribing Information.

https://www.gsksource.com/pharma/content/dam/GlaxoSmithKline/US/en/Prescribing_Information/Amerge/pdf/AMERGE-PI-PIL.PDF

Dailymed. Relpax Product Information.

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=85745375-fcb6-4edc-b6db-a77b4a5f3e8c&audience=consumer

Health Solutions From Our Sponsors