Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 2/23/2022

What is Amevive and how is it used?

Amevive is a prescription medicine used to treat the symptoms of Psoriasis. Amevive may be used alone or with other medications.

Amevive belongs to a class of drugs called Antipsoriatics, Systemic; Monoclonal Antibodies.

It is not known if Amevive is safe and effective in children.

What are the possible side effects of Amevive?

Amevive may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • chills,
  • cough,
  • fever,
  • hoarseness,
  • lower back or side pain,
  • painful or difficult urination,
  • body aches or pain,
  • congestion,
  • dry or sore throat,
  • runny nose,
  • tender or swollen glands in the neck,
  • trouble swallowing,
  • voice changes,
  • arm, back, or jaw pain,
  • chest pain or pressure,
  • fast or irregular heartbeat,
  • nausea,
  • vomiting,
  • shortness of breath, and
  • sweating

Get medical help right away, if you have any of the symptoms listed above.

The most common side effects of Amevive include:

  • difficulty moving,
  • dizziness,
  • itching,
  • joint pain,
  • muscle ache or cramps,
  • muscle pain or stiffness,
  • joint swelling, and
  • headache

Tell the doctor if you have any side effect that bothers you or that does not go away.

These are not all the possible side effects of Amevive. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


AMEVIVE® (alefacept) is a CD2-directed LFA-3/Fc fusion protein that consists of the extracellular CD2-binding portion of the human leukocyte function antigen-3 (LFA-3) linked to the Fc (hinge, CH2 and CH3 domains) portion of human IgGl. Alefacept is produced by recombinant DNA technology in a Chinese Hamster Ovary (CHO) mammalian cell expression system. The molecular weight of alefacept is 91.4 kilodaltons.

AMEVIVE® is supplied as a sterile, white-to-off-white, preservative-free, lyophilized powder for intramuscular administration. After reconstitution with 0.6 mL of the supplied Sterile Water for Injection, USP, the solution of AMEVIVE® is clear, with a pH of approximately 6.9.

AMEVIVE® for intramuscular injection contains alefacept (15 mg), citric acid monohydrate (0.06 mg), glycine (5 mg), sodium citrate dehydrate (3.6 mg), and sucrose (12.5 mg) per 0.5 mL of reconstituted solution.