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Last reviewed on RxList: 2/24/2017
Amicar Side Effects Center

Last reviewed on RxList 12/22/2016

Amicar (aminocaproic acid) acts as an inhibitor of fibrinolysis and is used to treat severe bleeding caused by problems with the blood clotting system, which helps you to stop bleeding. Aminocaproic acid works by affecting the blood clotting system, thereby slowing/stopping bleeding after surgery, in some bleeding conditions, or in severe liver disease. Amicar is available in generic form. Common side effects of Amicar include:

Tell your doctor if you have unlikely but serious side effects of Amicar including:

  • shortness of breath,
  • muscle pain/weakness,
  • changes in the amount of urine,
  • confusion,
  • slow heartbeat,
  • persistent sore throat, or
  • unusual bleeding or bruising.

For the treatment of acute bleeding syndromes due to elevated fibrinolytic activity, the dose of Amicar is five 1000 mg tablets, or ten 500 mg tablets, or 20 ml of oral solution (5 g) given during the first hour of treatment, followed by one 1000 mg tablet, or two 500 mg tablets, or 5 ml of oral solution (1.25 g) per hour. This is ordinarily continued for 8 hours or until bleeding is controlled. Amicar may interact with blood clotting factors, hormonal birth control, or estrogens. Tell your doctor all prescription and over-the-counter medications and supplements you use. During pregnancy, Amicar should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Our Amicar (aminocaproic acid) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Amicar Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using aminocaproic acid and call your doctor at once if you have a serious side effect such as:

  • sudden numbness or weakness, especially on one side of the body;
  • sudden headache, confusion, problems with vision, speech, or balance;
  • sudden cough, rapid breathing, fast heart rate;
  • pain or swelling in one or both legs;
  • muscle pain, tenderness, or weakness with fever or flu symptoms and dark colored urine;
  • urinating less than usual or not at all;
  • drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting;
  • swelling, weight gain, feeling short of breath;
  • slow heart rate, trouble breathing, feeling like you might pass out;
  • numbness or tingling in your arms or legs;
  • easy bruising or bleeding, purple or red pinpoint spots under your skin; or
  • confusion, hallucinations;

Less serious side effects may include:

  • mild muscle pain or weakness;
  • headache, tired feeling;
  • nausea, vomiting, stomach pain, diarrhea;
  • (in men) decreased amount of semen when having an orgasm;
  • stuffy nose, watery eyes
  • vision problems, ringing in your ears; or
  • mild skin rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Amicar (Aminocaproic Acid)

Amicar Professional Information


AMICAR (aminocaproic acid) is generally well tolerated. The following adverse experiences have been reported:


Edema, headache, malaise.

Hypersensitivity Reactions

Allergic and anaphylactoid reactions, anaphylaxis.


Bradycardia, hypotension, peripheral ischemia, thrombosis.


Abdominal pain, diarrhea, nausea, vomiting.


Agranulocytosis, coagulation disorder, leukopenia, thrombocytopenia.


CPK increased, muscle weakness, myalgia, myopathy (see WARNINGS), myositis, rhabdomyolysis.


Confusion, convulsions, delirium, dizziness, hallucinations, intracranial hypertension, stroke, syncope.


Dyspnea, nasal congestion, pulmonary embolism.


Pruritis, rash.

Special Senses

Tinnitus, vision decreased, watery eyes.


BUN increased, renal failure. There have been some reports of dry ejaculation during the period of AMICAR (aminocaproic acid) treatment. These have been reported to date only in hemophilia patients who received the drug after undergoing dental surgical procedures. However, this symptom resolved in all patients within 24 to 48 hours of completion of therapy.

Read the entire FDA prescribing information for Amicar (Aminocaproic Acid)

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© Amicar Patient Information is supplied by Cerner Multum, Inc. and Amicar Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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