Last updated on RxList: 3/5/2021
Amikin Side Effects Center

What Is Amikin?

Amikin (amikacin) is an aminoglycoside antibiotic used to treat serious bacterial infections. The brand name Amikin is no longer available in the U.S. Generic versions may still be available.

What Are Side Effects of Amikin?

Side effects of Amikin (amikacin) include:

Dosage for Amikin

Amikin is administered as an intravenous or intramuscular injection and the dose is determined by the patient's body weight.

What Drugs, Substances, or Supplements Interact with Amikin?

Amikin may interact with other drugs, especially those that affect the kidneys. Tell your doctor all medications and supplements you use.

Amikin During Pregnancy and Breastfeeding

Aminoglycosides, including Amikin, can cause fetal harm when administered to a pregnant woman. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. It is not known whether this drug is excreted in human milk. Consult your doctor before breastfeeding.

Additional Information

Our Amikin Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Amikin Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • hearing loss, or a roaring sound in your ears;
  • severe or ongoing dizziness;
  • kidney problems--little or no urinating; painful or difficult urination; swelling in your feet or ankles; feeling tired or short of breath;
  • weak or shallow breathing;
  • numbness or tingly feeling;
  • muscle twitching or seizure (convulsions); or
  • severe stomach pain, diarrhea that is watery or bloody.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Amikin (Amikacin)


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Amikin Professional Information


All aminoglycosides have the potential to induce auditory, vestibular, and renal toxicity and neuromuscular blockade (see WARNINGS box). They occur more frequently in patients with present or past history of renal impairment, of treatment with other ototoxic or nephrotoxic drugs, and in patients treated for longer periods and/or with higher doses than recommended.


Toxic effects on the eighth cranial nerve can result in hearing loss, loss of balance, or both. Amikacin primarily affects auditory function. Cochlear damage includes high frequency deafness and usually occurs before clinical hearing loss can be detected.

Neurotoxicity-Neuromuscular Blockade

Acute muscular paralysis and apnea can occur following treatment with aminoglycoside drugs.


Elevation of serum creatinine, albuminuria, presence of red and white cells, casts, azotemia, and oliguria have been reported. Renal function changes are usually reversible when the drug is discontinued. As would be expected with any aminoglycoside, reports of toxic nephropathy and acute renal failure have been received during postmarketing surveillance.


In addition to those described above, other adverse reactions which have been reported on rare occasions are skin rash, drug fever, headache, paresthesia, tremor, nausea and vomiting, eosinophilia, arthralgia, anemia, hypotension and hypomagnesemia. Macular infarction sometimes leading to permanent loss of vision has been reported following intravitreous administration (injection into the eye) of amikacin.

Read the entire FDA prescribing information for Amikin (Amikacin)

© Amikin Patient Information is supplied by Cerner Multum, Inc. and Amikin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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