Amphadase

Last updated on RxList: 7/2/2021
Amphadase Side Effects Center

What Is Amphadase?

Amphadase (hyaluronidase) is a genetically designed protein used as an aid in helping your body absorb other injected medications. Amphadase is also used to help contrast dyes in your body show more clearly on certain types of x-rays or scans.

What Are Side Effects of Amphadase?

Common side effects of Amphadase include:

  • injection site reactions (pain, itching, redness, tenderness, or swelling)
  • swelling in any part of the body

Dosage for Amphadase

The dose of Amphadase, the rate of injection, and the type of solution (saline, glucose, Ringer's, etc.) must be adjusted carefully to the individual patient. This medication is given as an injection under the skin.

What Drugs, Substances, or Supplements Interact with Amphadase?

Amphadase may interact with furosemide, phenytoin, sedatives or anxiety medications, aspirin or salicylates, cortisone or ACTH, estrogens, or antihistamines (such as a cold or allergy medicines). Tell your doctor all medications and supplements you use.

Amphadase During Pregnancy and Breastfeeding

During pregnancy, Amphadase should be used only if prescribed. It is unknown if this medication is harmful to a fetus. It is unknown if this drug passes into breast milk or if it could harm a nursing baby. Consult your doctor before breastfeeding.

Additional Information

Our Amphadase (hyaluronidase) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Amphadase Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • swelling in your hands, feet, or other body areas; or
  • pain, swelling, itching, or redness where the injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Amphadase (Hyaluronidase Injection)

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Digestive Disorders: Common Misconceptions See Slideshow
Amphadase Professional Information

SIDE EFFECTS

The following adverse reactions have been identified during post-approval use of hyaluronidase products. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. The most frequently reported adverse reactions have been local injection site reactions.

Hyaluronidase has been reported to enhance the adverse reactions associated with co-administered drug products. Edema has been reported most frequently in association with hypodermoclysis.

Allergic reactions (urticaria, angioedema) have been reported in less than 0.1% of patients receiving hyaluronidase. Anaphylactic-like reactions following retrobulbar block or intravenous injections have occurred, rarely.

DRUG INTERACTIONS

It is recommended that appropriate references be consulted regarding physical or chemical incompatibilities before adding Amphadase® to a solution containing another drug.

Incompatibilities

Furosemide, the benzodiazepines and phenytoin have been found to be incompatible with hyaluroniidase.

Drug-Specific Precautions

Hyaluronidase should not be used to enhance the dispersion and absorption of dopamine and/or alpha agonist drugs.

When considering the administration of any other drug with hyaluronidase, it is recommended that appropriate references first be consulted to determine the usual precautions for the use of the other drug; e.g., when epinephrine is injected along with hyaluronidase, the precautions for the use of epinephrine in cardiovascular disease, thyroid disease, diabetes, digital nerve block, ischemia of the fingers and toes etc., should be observed.

Local Anesthetics

When hyaluronidase is added to a local anesthetic agent, it hastens the onset of analgesia and tends to reduce the swelling caused by local infiltration, but the wider spread of the local anesthetic solution increases its absorption; this shortens its duration of action and tends to increase the incidence of systemic reaction.

Salicylates, Cortisone, ACTH, Estrogens And Antihistamines

Patients receiving large doses of salicylates, cortisone, ACTH, estrogens or antihistamines may require larger amounts of hyaluronidase for equivalent dispersing effect, since these drugs apparently render tissues partly resistant to the action of hyaluronidase.

Read the entire FDA prescribing information for Amphadase (Hyaluronidase Injection)

© Amphadase Patient Information is supplied by Cerner Multum, Inc. and Amphadase Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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