Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 8/9/2022

Drug Summary

What Is Ana-Kit?

Ana-Kit Adrenalin Chloride Solution (epinephrine injection) is a sympathomimetic agent used to relieve respiratory distress due to bronchospasm, to provide rapid relief of allergic reactions to drugs and other allergens, and to prolong the action of anesthetics. Ana-Kit Adrenalin Chloride Solution may restore cardiac rhythm in cardiac arrest due to various causes. Ana-Kit Adrenalin Chloride Solution may be available in generic form.

What Are Side Effects of Ana-Kit?

Common side effects of Ana-Kit Adrenalin Chloride Solution include:

  • anxiety
  • headache
  • fear, and palpitations
  • as well as injection site reactions

Ana-Kit may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • blurred vision,
  • chest pain or pressure,
  • confusion,
  • difficulty speaking,
  • severe dizziness,
  • double vision,
  • headache,
  • inability to move the arms, legs, or facial muscles,
  • nausea,
  • vomiting,
  • nervousness,
  • pain or discomfort in the arms, jaw, back, or neck,
  • pounding in the ears,
  • seizures,
  • slow or fast heartbeat,
  • slow speech,
  • sweating, and
  • tremors

Get medical help right away, if you have any of the symptoms listed above.

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheartedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Ana-Kit

Ana-Kit Adrenalin Chloride Solution is administered subcutaneously or intramuscularly at a dose of 0.2 to 1 mL (mg).

What Drugs, Substances, or Supplements Interact with Ana-Kit?

Ana-Kit Adrenalin Chloride Solution may interact with digitalis, diuretics, other drugs that sensitize the heart to arrhythmias, antidepressants, or antihistamines. Tell your doctor all medications and supplements you use.

Ana-Kit During Pregnancy or Breastfeeding

During pregnancy, Ana-Kit Adrenalin Chloride Solution should be used only if prescribed. Consult your doctor before breastfeeding.

Additional Information

Our Ana-Kit Adrenalin Chloride Solution (epinephrine injection) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

Drug Description


A sterile solution intended for subcutaneous or intramuscular injection. When diluted, it may also be administered intracardially or intravenously. Each milliliter contains 1 mg Adrenalin (epinephrine) as the hydrochloride dissolved in Water for Injection, USP, with sodium chloride added for isotonicity. The ampoules contain not more than 0.1% sodium bisulfite as an antioxidant, and the air in the ampoule has been displaced by nitrogen. The Steri-Vials® contain 0.5% Chlorobutanol (chloroform derivative) as a preservative and not more than 0.15% sodium bisulfite as an antioxidant. Epinephrine is the active principle of the adrenal medulla, chemically described as (—)-3,4-Dihydroxy-α-[(methylamino) methyl] benzyl alcohol, and has the following structural formula:

Epinephrine  structural formula illustration



In general, the most common uses of epinephrine are to relieve respiratory distress due to bron-chospasm, to provide rapid relief of hypersensitivity reactions to drugs and other allergens, and to prolong the action of infiltration anesthetics. Its cardiac effects may be of use in restoring cardiac rhythm in cardiac arrest due to various causes, but it is not used in cardiac failure or in hemorrhagic, traumatic, or cardiogenic shock.

Epinephrine is used as a hemostatic agent. It is also used in treating mucosal congestion of hay fever, rhinitis, and acute sinusitis; to relieve bronchial asthmatic paroxysms; in syncope due to complete heart block or carotid sinus hypersensitivity; for symptomatic relief of serum sickness, urticaria, angioneurotic edema; for resuscitation in cardiac arrest following anesthetic accidents; in simple (open angle) glaucoma; for relaxation of uterine musculature and to inhibit uterine contractions. Epinephrine injection can be utilized to prolong the action of intraspinal and local anesthetics (see CONTRAINDICATIONS section).



Parenteral drug products should be inspected visually for particulate matter and discoloration whenever solution and container permit.

Vial and contents must be discarded 30 days after initial use.

Subcutaneously or intramuscularly - 0.2 to 1 mL (mg). Start with a small dose and increase if required.

Note: The subcutaneous is the preferred route of administration. If given intramuscularly, injection into the buttocks should be avoided.

For bronchial asthma and certain allergic manifestations, e.g., angioedema, urticaria, serum sickness, anaphylactic shock, use epinephrine subcutaneously. For bronchial asthma in pediatric patients, administer 0.01 mg/kg or 0.3 mg/m2 to a maximum of 0.5 mg subcutaneously, repeated every four hours if required.

For cardiac resuscitation - A dose of 0.5 mL (0.5 mg) diluted to 10 mL with sodium chloride injection can be administered intravenously or intracardially to restore myocardial contrac-tility. External cardiac massage should follow intracardial administration to permit the drug to enter coronary circulation. The drug should be used secondarily to unsuccessful attempts with physical or electromechanical methods.

Ophthalmologic use (for producing conjunctival decongestion, to control hemorrhage, produce mydriasis and reduce intraocular pressure)—Use a concentration of 1:10,000 (0.1 mg/mL) to 1:1,000 (1 mg/mL).

Intraspinal use (Amp 88) - Usual dose is 0.2 to 0.4 mL (0.2 to 0.4 mg) added to anesthetic spinal fluid mixture (may prolong anesthetic action by limiting absorption). For use with local anesthetic—Epinephrine 1:100,000 (0.01 mg/mL) to 1:20,000 (0.05 mg/mL) is the usual concentration employed with local anesthetics.


NDC 61570-418-81 (Amp 88) Sterile solution containing 1 mg Adrenalin (epinephrine) as the hydrochloride in each 1-mL ampoule (1:1000). For intramuscular or subcutaneous use. When diluted, it may also be administered intracardially, intravenously, or intraspinally. Supplied in packages of ten.

NDC 61570-401-11 (S.V. 11) Sterile solution containing 1 mg Adrenalin (epinephrine) as the hydrochloride (1:1000). For intramuscular or subcutaneous use. When diluted, it may also be administered intracardially or intravenously. Supplied in a 30-mL Steri-Vial® (rubber-diaphragm-capped vial).

Store between 15° and 25°C (59° and 77°F).

Protect from light and freezing.

Manufactured for: Monarch Pharmaceuticals, Inc., Bristol, TN 37620. By: Parkedale Pharmaceuticals, Inc., Rochester, MI 48307. FDA rev date: n/a

Side Effects & Drug Interactions


Transient and minor side effects of anxiety, headache, fear, and palpitations often occur with therapeutic doses, especially in hyperthyroid individuals. Repeated local injections can result in necrosis at sites of injection from vascular constriction. "Epinephrine-fastness" can occur with prolonged use.


Use of epinephrine with excessive doses of digitalis, mercurial diuretics, or other drugs that sensitize the heart to arrhythmias is not recommended. Anginal pain may be induced when coronary insufficiency is present.

The effects of epinephrine may be potentiated by tricyclic antidepressants; certain antihista-mines, e.g., diphenhydramine, tripelennamine, d-chlorpheniramine; and sodium l-thyroxine.



Administer with caution to elderly people; to those with cardiovascular disease, hypertension, diabetes, or hyperthyroidism; in psychoneurotic individuals; and in pregnancy.

Patients with long-standing bronchial asthma and emphysema who have developed degenerative heart disease should be administered the drug with extreme caution.

Overdosage or inadvertent intravenous injection of epinephrine may cause cerebrovascular hemorrhage resulting from the sharp rise in blood pressure.

Fatalities may also result from pulmonary edema because of the peripheral constriction and cardiac stimulation produced. Rapidly acting vasodilators, such as nitrites, or alpha blocking agents may counteract the marked pressor effects of epinephrine.

Epinephrine is the preferred treatment for serious allergic or other emergency situations even though this product contains sodium bisulfite, a sulfite that may in other products cause allergic-type reactions including anaphylactic symptoms or life-threatening or less severe asthmatic episodes in certain susceptible persons. The alternatives to using epinephrine in a life-threatening situation may not be satisfactory. The presence of a sulfite in this product should not deter administration of the drug for treatment of serious allergic or other emergency situations.




Adrenalin (epinephrine injection, USP) should be protected from exposure to light. Do not remove ampoules or syringes from carton until ready to use. The solution should not be used if it is pinkish or darker than slightly yellow or if it contains a precipitate.

Epinephrine is readily destroyed by alkalies and oxidizing agents. In the latter category are oxygen, chlorine, bromine, iodine, permanganates, chromates, nitrites, and salts of easily reducible metals, especially iron.

Usage in Pregnancy

Pregnancy Category C. Adrenalin (epinephrine) has been shown to be teratogenic in rats when given in doses about 25 times the human dose. There are no adequate and well-controlled studies in pregnant women. Adrenalin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Overdose & Contraindications


No information provided.


Epinephrine is contraindicated in narrow angle (congestive) glaucoma, shock, during general anesthesia with halogenated hydrocarbons or cyclopropane and in individuals with organic brain damage. Epinephrine is also contraindicated with local anesthesia of certain areas, e.g., fingers, toes, because of the danger of vasoconstriction producing sloughing of tissue; in labor because it may delay the second stage; in cardiac dilatation and coronary insufficiency.

Clinical Pharmacology


Adrenalin (epinephrine) is a sympathomimetic drug. It activates an adrenergic receptive mechanism on effector cells and imitates all actions of the sympathetic nervous system except those on the arteries of the face and sweat glands. Epinephrine acts on both alpha and beta receptors and is the most potent alpha receptor activator.

Medication Guide


No information provided. Please refer to the WARNINGS and PRECAUTIONS sections.

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