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Last reviewed on RxList: 2/18/2016
Ancobon Side Effects Center

Last reviewed on RxList 2/11/2016

Ancobon (flucytosine) is an antifungal medication used to treat serious fungal infections of the blood, lungs, heart, central nervous system, and urinary tract. Ancobon is available in generic form. Common side effects of Ancobon include nausea, vomiting, diarrhea, decreased appetite, dry mouth, headache, drowsiness, weakness, or poor coordination.

The usual dosage of Ancobon is 50 to 150 mg/kg/day administered in divided doses at 6-hour intervals. Nausea or vomiting may be reduced or avoided if the capsules are given a few at a time over a 15-minute period. Ancobon may interact with amphotericin B, or cytosine. Tell your doctor all medications and supplements you use. During pregnancy, Ancobon should be used only when prescribed. It is not recommended for use during the first 3 months of pregnancy. It may harm a fetus. It is unknown if this drug passes into breast milk. It may have undesirable effects on a nursing infant. Breastfeeding while using this drug is not recommended.

Our Ancobon (flucytosine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Ancobon Consumer Information

If you experience any of the following serious side effects, stop taking flucytosine and seek emergency medical attention or contact your doctor immediately:

  • an allergic reaction (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);
  • chest pain;
  • yellowing of the skin or eyes;
  • little or no urine;
  • confusion or hallucinations;
  • numbness or tingling; or
  • hearing loss.

Other, less serious side effects may be more likely to occur. Continue to take flucytosine and talk to your doctor if you experience

  • nausea, vomiting, decreased appetite, or diarrhea;
  • a dry mouth;
  • headache;
  • sedation; or
  • weakness or poor coordination.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Ancobon (Flucytosine)

Ancobon Professional Information


The adverse reactions which have occurred during treatment with Ancobon are grouped according to organ system affected.

Cardiovascular: Cardiac arrest, myocardial toxicity, ventricular dysfunction.

Respiratory: Respiratory arrest, chest pain, dyspnea.

Dermatologic: Rash, pruritus, urticaria, photosensitivity.

Gastrointestinal: Nausea, emesis, abdominal pain, diarrhea, anorexia, dry mouth, duodenal ulcer, gastrointestinal hemorrhage, acute hepatic injury including hepatic necrosis with possible fatal outcome in debilitated patients, hepatic dysfunction, jaundice, ulcerative colitis, enterocolitis, bilirubin elevation, increased hepatic enzymes.

Genitourinary: Azotemia, creatinine and BUN elevation, crystalluria, renal failure.

Hematologic: Anemia, agranulocytosis, aplastic anemia, eosinophilia, leukopenia, pancytopenia, thrombocytopenia, and fatal cases of bone marrow aplasia.

Neurologic: Ataxia, hearing loss, headache, paresthesia, parkinsonism, peripheral neuropathy, pyrexia, vertigo, sedation, convulsions.

Psychiatric: Confusion, hallucinations, psychosis.

Miscellaneous: Fatigue, hypoglycemia, hypokalemia, weakness, allergic reactions, Lyell's syndrome.

Read the entire FDA prescribing information for Ancobon (Flucytosine)

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© Ancobon Patient Information is supplied by Cerner Multum, Inc. and Ancobon Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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