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Angiotensin Receptor Blockers (ARBs) (cont.)

Pharmacy Author:
Medical Editor:

With which drugs do ARBs interact?

ARBs have few interactions with other drugs.

Fluconazole (Diflucan) impairs the conversion of losartan (Cozaar) to its active form, and rifamycin (Rifampin) reduces blood levels of losartan (Cozaar). Thus, both drugs may reduce the activity of losartan (Cozaar).

Combining ARBs with potassium supplements, salt substitutes (often contain potassium), or other drugs that increase potassium (for example, spironolactone), may result in excessive blood potassium levels (hyperkalemia) because ARBs also increase potassium levels. ARBs may also may increase the blood concentration of lithium (Eskalith) and lead to an increase in side effects from lithium (Eskalith).

What are some examples of ARBs available in the United States?

Examples of ARBs include:

ARBs combined with hydrochlorothiazide or other antihypertensives are also available, for example:

  • amlodipine and valsartan (Exforge),
  • irbesartan-hydrochlorothiazide (Avalide),
  • losartan potassium-hydrochlorothiazide (Hyzaar), and
  • valsartan and hydrochlorothiazide (Diovan HCT).

Reviewed by:

Robert J. Bryg, MD

Board Certified Internal Medicine with subspecialty in Cardiovascular Disease

Last Editorial Review: 12/4/2008


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