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Antabuse vs. Vivitrol

Are Antabuse and Vivitrol the Same Thing?

Antabuse (disulfiram) and Vivitrol (naltrexone) are used to treat chronic alcoholism.

Vivitrol is also used to prevent relapse to opioid dependence.

Antabuse and Vivitrol belong to different drug classes. Antabuse is an alcohol antagonist and Vivitrol is an opioid antagonist.

What Are Possible Side Effects of Antabuse?

Common side effects of Antabuse include:

Tell your doctor if you have a unlikely but serious side effects of Antabuse including:

  • vision changes,
  • numbness or tingling of arms and legs,
  • muscle weakness,
  • mental/mood changes (e.g., agitation, extreme excitement/confusion), or
  • seizures.

What Are Possible Side Effects of Vivitrol?

Common side effects of Vivitrol include:

  • nausea,
  • headache,
  • dizziness,
  • anxiety,
  • nervousness,
  • restlessness,
  • irritability,
  • tiredness,
  • loss of appetite,
  • increased thirst,
  • muscle or joint aches,
  • weakness,
  • sleep problems (insomnia),
  • decreased sex drive,
  • impotence, or
  • difficulty having an orgasm.

What Is Antabuse?

Antabuse (disulfiram) is an alcohol antagonist drug used to treat chronic alcoholism. Antabuse is available in generic form.

What Is Vivitrol?

Vivitrol (naltrexone) for Extended-Release Injectable Suspension is an opioid antagonist used to treat alcohol dependence and prevent relapse to opioid dependence.

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What Drugs Interact With Antabuse?

Antabuse may interact with isoniazid, monoamine oxidase inhibitors (MAOIs), benzodiazepines, tricyclic antidepressants, warfarin, metronidazole, theophylline, phenytoin, or lithium. Tell your doctor all medications you are taking. During pregnancy, Antabuse should be used only when prescribed.

What Drugs Interact With Vivitrol?

Vivitrol may interact with narcotic pain medications including buprenorphine, butorphanol, codeine, hydrocodone, hydromorphone, levorphanol, meperidine, methadone, morphine, nalbuphine, naloxone, oxycodone, oxymorphone, or propoxyphene. Tell your doctor all medications and supplements you take. Do not use narcotic drugs or alcohol while taking Vivitrol. Exercise caution if you drive or do anything that requires you to be alert while taking Vivitrol.

How Should Antabuse Be Taken?

In the first phase of treatment, a maximum of 500 mg of Antabuse daily is given in a single dose for one to two weeks. The average maintenance dose of Antabuse is 250 mg daily (range, 125 to 500 mg), not to exceed 500 mg daily. Do not drink alcohol and avoid all alcohol-containing products (e.g., cough and cold syrups, mouthwash, or foods containing alcohol) while taking this medication.

How Should Vivitrol Be Taken?

The recommended dosage of Vivitrol is 380 mg taken once a month. Vivitrol must be administered under a doctor's supervision.

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References

DailyMed. Antabuse Product Information.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=12850de3-c97c-42c1-b8d3-55dc6fd05750
DailyMed. Vivitrol Product Information.
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=cd11c435-b0f0-4bb9-ae78-60f101f3703f

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