How Do First Generation Antihistamines Work?

Reviewed on 10/13/2021

HOW DO FIRST-GENERATION ANTIHISTAMINES WORK?

First-generation antihistamines are a type of antihistamines that are effective against allergies, colds, and cough.

They work by binding to the histamine receptors in the brain and spinal cord and blocking the release of histamine. Excess release of histamine can cause the following allergic reactions:

Thus, antihistamines reduce allergic symptoms by preventing the release of histamine. First-generation antihistamines were the first type of antihistamines to be approved by the FDA. The most prominent side effect of first-generation antihistamines is that they cross the blood-brain barrier leading to drowsiness.

HOW ARE FIRST-GENERATION ANTIHISTAMINES USED?

First-generation antihistamines are used for treating:

WHAT ARE SIDE EFFECTS OF FIRST-GENERATION ANTIHISTAMINES?

First-generation antihistamines can cross the blood-brain barrier, leading to a feeling of drowsiness. Other symptoms of first-generation antihistamines include:

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

QUESTION

Allergies can best be described as: See Answer

WHAT ARE NAMES OF FIRST-GENERATION ANTIHISTAMINES?

Generic and brand names of first-generation antihistamines include:

  • Alka-Seltzer Plus Allergy
  • Benadryl
  • Benadryl Allergy Dye-Free LiquiGels
  • Brompheniramine
  • Carbinoxamine
  • Children's benadryl allergy
  • Children's triaminic thin strips allergy
  • Chlorpheniramine
  • Chlortrimeton
  • Clemastine
  • Cyproheptadine
  • Dexchlorpheniramine
  • Diabetic tussin
  • Dimenhydrinate
  • Dimetane
  • Diphenhydramine
  • Dramamine
  • Histex
  • Histex PD Drops
  • Hydroxyzine
  • Karbinal ER
  • M-Hist PD
  • Nytol
  • PediaCare Children's Allergy
  • Phenadoz
  • Phenergan
  • Promethazine
  • QlearQuil Nighttime Allergy Relief
  • Respa-BR
  • Simply Sleep
  • Sominex
  • Tranquil Nighttime Sleep Aid
  • Triprolidine
  • Unisom SleepGels
  • Unisom SleepMelts
  • Vanaclear PD
  • Vanahist PD
  • Vistaril
  • ZzzQuil
References
https://reference.medscape.com/drugs/antihistamines-1st-generation

https://my.clevelandclinic.org/health/drugs/21223-antihistamines

Health Solutions From Our Sponsors