How Do Antimalarial Artemisinin Derivatives Work?

Reviewed on 9/29/2021

HOW DO ANTIMALARIAL ARTEMISININ DERIVATIVES WORK?

Antimalarial artemisinin derivatives are a new class of antimalarial drugs used as initial treatment for severe malaria. These drugs inhibit growth and eventually kill the parasite.

Artesunate, an artemisinin derivative, is a prodrug, which is metabolized into dihydroartemisinin (DHA). The endoperoxide bridge present in artesunate and DHA reacts with heme iron and leads to oxidative stress. This inhibits the synthesis of proteins and nucleic acids in the Plasmodium parasite in all blood stages such as asexual parasites and gametocytes. The absence of proteins and nucleic acids leads to a decrease in the growth and survival rate of the parasite.

HOW ARE ANTIMALARIAL ARTEMISININ DERIVATIVES USED?

Antimalarial artemisinin derivatives are administered as intravenous injections to treat severe malaria.

WHAT ARE SIDE EFFECTS OF ANTIMALARIAL ARTEMISININ DERIVATIVES? 

Side effects associated with antimalarial artemisinin derivatives include:

 

The information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE NAMES OF ANTIMALARIAL ARTEMISININ DERIVATIVES?

Generic name of antimalarial artemisinin derivative is:

  • Artesunate

QUESTION

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References
https://reference.medscape.com/drugs/antimalarials-artemisinin-derivative

https://www.sciencedirect.com/topics/neuroscience/artemisinin-derivative#:~:text=The%20four%20WHO%2Drecommended%20oral,falciparum%20malaria%20in%20endemic%20countries.

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