How Do Antimanic Agents Work?

Reviewed on 1/10/2022

How Do Antimanic Agents Work?

Antimanic agents are medications used as mood stabilizers in psychiatric conditions such as bipolar disorder and schizophrenia. In addition, some antimanic agents control abnormal electrical activity in the brain and are used to treat neurological conditions such as epilepsy and trigeminal neuralgia.

Antimanic agents control mania, an extremely euphoric and excited mood associated with psychiatric disorders. Antimanic agents also control involuntary muscle contractions or pain caused by the abnormal firing of nerve cells (neurons). Antimanic agents work by regulating the chemical balance and activity, and electrical activity in the brain.

Antimanic agents help reduce manic excitement by acting on several neurotransmitters such as dopamine, serotonin and norepinephrine, which are chemical messengers that neurons release to communicate with each other and stimulate activity. 

Antimanic agents primarily block D2 dopamine receptors and 5-HT2A serotonin receptors, which are protein molecules that initiate excitatory action when stimulated by these neurotransmitters. Some antimanic agents stimulate H1 histamine receptors in the central nervous system, producing sedation and calming effects. 

Antimanic agents prevent abnormal electrical impulses by stabilizing the sodium channels in neurons and reducing their electrical conductivity.

How Are Antimanic Agents Used?

Antimanic agents are used to treat the following conditions:


  • Schizophrenia
  • Bipolar I disorder mania
  • Major depressive disorder
  • Autism
  • Tourette syndrome (a nervous system disorder involving repetitive movements or unwanted sounds)
  • Epilepsy
  • Trigeminal neuralgia
  • Bipolar I disorder (manic or mixed episodes)
  • Bipolar I disorder maintenance
  • Agitation associated with schizophrenia and bipolar I mania
  • Bipolar depression

Off-label uses:

Orphan designation:

  • N-glycanase 1 deficiency


Another term that has been previously used for bipolar disorder is ___________________. See Answer

What Are Side Effects of Antimanic Agents?

Side effects of antimanic agents may include the following:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

What Are Names of Some Antimanic Drugs?

Generic and brand names of antimanic drugs include:


What Is Bipolar Disorder? Symptoms, Manic Episodes, Testing See Slideshow

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