How Do Ankylating Antineoplastics Work?

Reviewed on 1/10/2022

HOW DO ALKYLATING ANTINEOPLASTICS WORK?

Alkylating antineoplastics are a class of drugs used to treat various types of cancers such as multiple myeloma (a type of cancer of the bone marrow), ovarian cancer (cancer that begins in the female reproductive organs), brain tumors, Hodgkin's disease (a malignant though often curable disease of lymphatic tissues, typically causing painless enlargement of the lymph nodes, liver, and spleen), non-Hodgkin's lymphoma (cancer that begins in the cells of the immune system), certain types of leukemia (cancer of the white blood cells) including chronic lymphocytic leukemia and chronic myelogenous leukemia, and lung cancer.

Alkylating antineoplastics are administered orally once a day on an empty stomach and as a powder to be mixed with liquid to be injected intravenously (into a vein) over one minute or infused intravenously over 15 to 30 minutes.

Alkylating antineoplastics work in the following ways:

  • They belong to a class known as "alkylating agents" that work by stopping or slowing the growth of cancer cells in the body.
  • They belong to a class of medications called “platinum-containing antineoplastic agents” that work by suppressing the body's immune system.

HOW ARE ALKYLATING ANTINEOPLASTICS USED?

Alkylating antineoplastics are used to treat conditions such as:

SLIDESHOW

Understanding Cancer: Metastasis, Stages of Cancer, and More See Slideshow

WHAT ARE SIDE EFFECTS OF ALKYLATING ANTINEOPLASTICS?

Some of the common side effects include:

Other rare side effects include:

 

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE NAMES OF ALKYLATING ANTINEOPLASTICS?

Generic and brand names of alkylating antineoplastics include:

References
https://reference.medscape.com/drugs/antineoplastics-alkylating

https://www.webmd.com/drugs/2/drug-5234/melphalan-oral/details

https://medlineplus.gov/druginfo/meds/a682220.html

https://www.rxlist.com/thiotepa-drug.htm#description

https://medlineplus.gov/druginfo/meds/a601250.html

https://www.webmd.com/drugs/2/drug-8756/cisplatin-intravenous/details

https://medlineplus.gov/druginfo/meds/a682248.html

https://www.rxlist.com/busulfex-drug.htm

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