How Do Anaplastic Lymphoma Kinase Inhibitor Work?

Reviewed on 1/10/2022

HOW DO ANAPLASTIC LYMPHOMA KINASE INHIBITORS WORK?

Anaplastic lymphoma kinase (ALK) inhibitors are a class of drugs used to treat adult patients with ALK-positive metastatic nonsmall cell lung cancer (NSCLC) that has spread to nearby tissues or other parts of the body. They are “tyrosine kinase inhibitors” that selectively and potently inhibit ALK, a protein that helps control cell growth. Blocking this protein may help prevent cancer cells from growing and spreading. 

ALK inhibitors are administered orally with or without food and work in the following ways:

  • They belong to a class known as “kinase inhibitors” that work by blocking the action of an abnormal protein that signals cancer cells to multiply.
  • This helps slow down or stop the spread of cancer cells.
  • They inhibit the activity of ALK, a protein essential for the development and function of nervous system tissue
  • However, chromosomal translocation and fusion give rise to an oncogenic form of ALK that has been implicated in the progression of NSCLC.
  • They inhibit this mutated enzyme and stop cell proliferation, ultimately halting cancer progression.

HOW ARE ANAPLASTIC LYMPHOMA KINASE INHIBITORS USED?

ALK inhibitors are used to treat ALK-positive metastatic NSCLC.

SLIDESHOW

Lung Cancer: Early Signs, Symptoms, Stages See Slideshow

WHAT ARE SIDE EFFECTS OF ANAPLASTIC LYMPHOMA KINASE INHIBITORS?

Some of the common side effects include:

Other rare side effects include:

 

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE NAMES OF ANAPLASTIC LYMPHOMA KINASE INHIBITORS?

Generic and brand names of anaplastic lymphoma kinase inhibitors include:

References
https://reference.medscape.com/drugs/antineoplastics-anaplastic-lymphoma-kinase-inhibitor

https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-brigatinib-alk-positive-metastatic-nsclc

https://www.webmd.com/drugs/2/drug-166222/ceritinib-oral/details

https://medlineplus.gov/druginfo/meds/a617016.html

https://medlineplus.gov/druginfo/meds/a614027.html

https://medlineplus.gov/druginfo/meds/a612018.html

https://medlineplus.gov/druginfo/meds/a619005.html

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