How Do Antineoplastic Camptothecins Work?

Reviewed on 10/25/2021

HOW DO ANTINEOPLASTICS CAMPTOTHECINS WORK?

Antineoplastic camptothecins (CPTs) are a class of drugs used to treat various types of cancers including pancreatic cancer, colon or rectal cancer (cancer that begins in the large intestine), ovarian cancer (cancer that begins in the female reproductive organs where eggs are formed), cervical cancer (cancer that begins in the opening of the uterus), and small cell lung cancer.

CPTs are anticancer drugs isolated from the bark and stem of Camptotheca acuminata, a tree native to China used in traditional Chinese medicine. They selectively inhibit the nuclear enzyme DNA topoisomerase, type I and possess antitumor activity. They are potent topoisomerase inhibitors that interfere with the essential function of topoisomerase in DNA replication.

Antineoplastics CPTs are administered via intravenous (into a vein) route.

Antineoplastics CPTs work in the following ways:

  • They belong to a class of antineoplastic medications called “topoisomerase I inhibitors” that work by slowing down or stopping the growth of cancer cells.
  • They inhibit the action of topoisomerase I which prevents religation of the DNA strand by binding to topoisomerase I-DNA complex and causes breaking of double-strand DNA, thus leading to apoptosis (cell death).

HOW ARE ANTINEOPLASTICS CAMPTOTHECINS USED?

Antineoplastics CPTs are used to treat conditions such as:

WHAT ARE SIDE EFFECTS OF ANTINEOPLASTICS CAMPTOTHECINS?

Some of the common side effects include:

Other rare side effects include:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

 

SLIDESHOW

Digestive Disorders: Common Misconceptions See Slideshow

WHAT ARE NAMES OF ANTINEOPLASTICS CAMPTOTHECINS?

Generic and brand names of antineoplastics CPTs include:

References
https://reference.medscape.com/drugs/antineoplastics-camptothecin

https://www.rxlist.com/onivyde-drug.htm#indications

https://medlineplus.gov/druginfo/meds/a608043.html

https://medlineplus.gov/druginfo/meds/a697006.html

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