How Do Antineoplastic EGFR Inhibitors Work?

Reviewed on 10/25/2021

HOW DO ANTINEOPLASTIC EGFR INHIBITORS WORK?

Antineoplastic epidermal growth factor receptor (EGFR) inhibitors are a class of drugs used to treat hormone receptor-positive breast cancer (breast cancer that depends on hormones such as estrogen to grow), medullary thyroid cancer, advanced head and neck cancer, metastatic colorectal cancer, non-small cell lung cancer, and pancreatic cancer.

EGFR inhibitors are anti-cancer medications that block the activity of a protein called EGFR. EGFR is found on the surface of some normal cells and is involved in cell growth, also found at high levels on some types of cancer cells, which causes these cells to grow and divide. Blocking EGFR helps in preventing unregulated cell division, thus preventing the growth, and spread of cancer cells.

EGFR inhibitors can be classified into the following:

EGFR inhibitors are administered via intravenous (into a vein) and oral routes.

EGFR inhibitors work in the following ways:

  • They belong to a class of medications called “tyrosine kinase inhibitors” that work by slowing down or stopping the growth of cancer cells.
  • They work by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps slow or stop the spread of cancer cells.
  • They block the activity of a protein called "EGFR" and thus prevent unregulated cell division.

HOW ARE ANTINEOPLASTIC EGFR INHIBITORS USED?

Antineoplastic EGFR inhibitors are used to treat conditions such as:

 

WHAT ARE SIDE EFFECTS OF ANTINEOPLASTIC EGFR INHIBITORS?

Some of the common side effects include:

Other rare side effects include:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

SLIDESHOW

Breast Cancer Awareness: Symptoms, Diagnosis, and Treatment See Slideshow

WHAT ARE NAMES OF ANTINEOPLASTIC EGFR INHIBITORS?

Generic and brand names of antineoplastic EGFR inhibitors include:

References
https://reference.medscape.com/drugs/antineoplastics-egfr-inhibitor

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958662/

https://www.webmd.com/drugs/2/drug-147806/lapatinib-oral/details

https://www.webmd.com/drugs/2/drug-155643/vandetanib-oral/details

https://www.rxlist.com/erbitux-drug.htm

https://www.rxlist.com/vectibix-drug.htm

https://medlineplus.gov/druginfo/meds/a605008.html

https://medlineplus.gov/druginfo/meds/a617034.html

https://www.rxlist.com/consumer_portrazza_necitumumab/drugs-condition.htm

https://medlineplus.gov/druginfo/meds/a607066.html

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