HOW DO ANTINEOPLASTIC PLATINUM ANALOGS WORK?
Antineoplastic platinum analogs are a class of drugs used alone or in combination with other medications to treat ovarian cancer (cancer that begins in the female reproductive organ where eggs are formed), colon or rectal cancer (cancer that begins in the large intestine), metastatic testicular tumors, and advanced bladder cancer.
Chemotherapy is often given as a combination of drugs. Platinum analogs are antineoplastic alkylating agents used to treat approximately half of the patients receiving chemotherapy for cancer.
Alkylating agents work by three different mechanisms:
- Preventing DNA synthesis: attachment of alkyl groups to DNA bases, resulting in the DNA fragmentation by repair enzymes in their attempts to replace the alkylated bases
- DNA damage: via the formation of cross-links (bonds between atoms in the DNA) which prevent DNA from being separated for synthesis or transcription
- Induction of mispairing of the nucleotides, leading to mutations (a change in a DNA sequence)
Platinum analogs are administered as a solution (liquid) to be injected intravenously (into a vein). Platinum analogs are chemotherapy drugs containing platinum that work by stopping or slowing the growth of cancer cells.
HOW ARE ANTINEOPLASTIC PLATINUM ANALOGS USED?
Antineoplastic platinum analogs are used to treat conditions such as:
WHAT ARE SIDE EFFECTS OF ANTINEOPLASTIC PLATINUM ANALOGS?
Some of the common side effects include:
- Mouth sores
- Altered taste sensation
- Abdominal pain
- Loss of appetite
- Joint/muscle pain
- Pain, redness, swelling, hardness, or itching at the injection site
- Other rare side effects include:
- Hair loss
- Shortness of breath
- Chills, sore throat, fever, or cough
- Blurred vision
- Decreased urination
- Anemia (low red blood cell count)
- Thrombocytopenia (low blood platelet count)
- Elevated liver enzymes
- Swelling of the face, arms, hands, feet, ankles, or lower legs
- Tinnitus (ringing in the ears)
- Peripheral neuropathy (damage to one or more groups of nerves)
Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.