How Do Antineoplastic Retinoids Work?

Reviewed on 10/20/2021

HOW DO ANTINEOPLASTIC RETINOIDS WORK?

Antineoplastic retinoids are a class of drugs used to treat skin manifestations of cutaneous T-cell lymphoma (a type of skin cancer), skin lesions in patients with AIDS-related Kaposi's sarcoma (cancer that develops from the cells that line the lymph or blood vessels).

Antineoplastic retinoids are derivatives of vitamin A used orally or topically for the treatment of skin manifestations of certain cancers. They selectively bind to and activate retinoid X receptors which regulate cell proliferation, differentiation, and apoptosis (death of cells that occurs as a normal and controlled part of an organism's growth or development). Once activated, these receptors function as transcription factors that regulate the expression of genes that control cellular differentiation and proliferation. They also possess antiangiogenic (the ability to reduce unwanted growth of blood vessels) activity and inhibit cancer metastasis.

Antineoplastic retinoids are administered via oral and topical routes.

HOW ARE ANTINEOPLASTIC RETINOIDS USED?

Antineoplastic retinoids are used to treat conditions such as:

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WHAT ARE SIDE EFFECTS OF ANTINEOPLASTIC RETINOIDS?

Some of the common side effects include:

Other rare side effects include:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

WHAT ARE NAMES OF ANTINEOPLASTIC RETINOIDS?

Generic and brand names of antineoplastic retinoids include:

References
https://reference.medscape.com/drugs/antineoplastics-retinoids

https://www.webmd.com/drugs/2/drug-17968/bexarotene-oral/details

https://www.webmd.com/drugs/2/drug-16973/alitretinoin-topical/details

https://www.rxlist.com/panretin-drug.htm

https://medlineplus.gov/druginfo/meds/a601012.html

https://medlineplus.gov/druginfo/meds/a608006.html

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