Antizol Side Effects Center

Last updated on RxList: 1/8/2021
Antizol Side Effects Center

What Is Antizol?

Antizol (fomepizole) is an antidote used to treat poisoning with ethylene glycol (antifreeze) or methanol (contained in solvents, fuels, and other household or automotive chemicals). Antizol is sometimes used together with hemodialysis to rid the body of a poison. Antizol is available in generic form.

What Are Side Effects of Antizol?

Common side effects of Antizol include:

Dosage for Antizol

Antizol is administered in a clinical setting and dose is determined by a physician.

What Drugs, Substances, or Supplements Interact with Antizol?

Antizol may interact with phenytoin, carbamazepine, cimetidine, or ketoconazole. Tell your doctor all medications and supplements you use.

Antizol During Pregnancy and Breastfeeding

Antizol may be harmful to a fetus and is not recommended in pregnant women unless prescribed. It is unknown if this drug passes into breast milk or if it could harm a nursing baby. In a poisoning situation, it may not be possible to tell your caregivers that you are pregnant or breastfeeding before you are treated with Antizol. Make sure any doctor caring for your pregnancy or your baby knows you have received the medication.

Additional Information

Our Antizol (fomepizole) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Antizol Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your caregiver right away if you have:

  • skin rash, bruising, severe tingling, numbness, pain, muscle weakness.
  • severe nausea, severe dizziness or spinning sensation; or
  • a light-headed feeling, like you might pass out.

Common side effects may include:

  • headache;
  • dizziness, drowsiness;
  • nausea; or
  • unpleasant or metallic taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Antizol (Fomepizole)


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Antizol Professional Information


The most frequent adverse events reported as drug-related or unknown relationship to study drug in the 78 patients and 63 normal volunteers who received Antizol® (fomepizole) Injection were headache (14%), nausea (11%), and dizziness, increased drowsiness, and bad taste/metallic taste (6% each). All other adverse events in this population were reported in approximately 3% or fewer of those receiving Antizol (fomepizole) and were as follows:

Body as a Whole: Abdominal pain, fever, multiorgan system failure, pain during Antizol (fomepizole) injection, inflammation at injection site, lumbalgia/backache, hangover

Cardiovascular: Sinus bradycardia/bradycardia, phlebosclerosis, tachycardia, phlebitis, shock, hypotension

Gastrointestinal: Vomiting, diarrhea, dyspepsia, heartburn, decreased appetite, transient transaminitis

Hemic/Lymphatic: Eosinophilia/hypereosinophilia, lymphangitis, disseminated intravascular coagulation, anemia

Nervous: Lightheadedness, seizure, agitation, feeling drunk, facial flush, vertigo, nystagmus, anxiety, "felt strange", decreased environmental awareness

Respiratory: Hiccups, pharyngitis

Skin/Appendages: Application site reaction, rash

Special Senses: Abnormal smell, speech/visual disturbances, transient blurred vision, roar in ear

Urogenital: Anuria

Read the entire FDA prescribing information for Antizol (Fomepizole)

© Antizol Patient Information is supplied by Cerner Multum, Inc. and Antizol Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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