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Anusol Hc

Last reviewed on RxList: 7/28/2016
Anusol Hc Side Effects Center

Last reviewed on RxList 10/28/2016

Anusol-HC (hydrocortisone acetate rectal suppositories, 25 mg) is a corticosteroid indicated for use in inflamed hemorrhoids, post-irradiation (factitial) proctitis, as an adjunct in the treatment of chronic ulcerative colitis, cryptitis, other inflammatory conditions of the anorectum, and anal itching (pruritis ani). Anusol-HC is available in generic form. Common side effects of Anusol-HC include:

  • Application site reactions (rectal pain, redness, burning, itching, irritation, dryness)
  • Acne
  • Changes in menstrual periods
  • Increased sweating
  • Increased facial or body hair growth
  • Inflammation of hair follicles (folliculitis)
  • Lightening of skin color
  • Allergic skin rash
  • Secondary infection

The usual dosage of Anusol-HC is one suppository in the rectum morning and night for two weeks, in nonspecific proctitis. In more severe cases, one suppository three times daily; or two suppositories twice daily. Anusol-HC may interact with other drugs. Tell your doctor all medications and supplements you use. During pregnancy, Anusol-HC should be used only if prescribed. Corticosteroids such as Anusol-HC should not be used extensively on pregnant patients, in large amounts, or for prolonged periods of time. It is unknown if Anusol-HC passes into breast milk. Breastfeeding while using Anusol-HC is not recommended.

Our Anusol-HC (hydrocortisone acetate rectal suppositories, 25 mg) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Anusol Hc Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • feeling short of breath, even with mild exertion;
  • swelling of your ankles or feet;
  • muscle weakness;
  • rapid weight gain, especially in your face and midsection;
  • severe rectal pain or burning;
  • bleeding from your rectum;
  • severe stomach pain;
  • sudden and severe headache or pain behind your eyes; or
  • seizure (convulsions).

Less serious side effects may include:

  • mild rectal pain or burning;
  • acne;
  • changes in your menstrual periods;
  • increased sweating; or
  • increased facial or body hair growth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Anusol Hc (Hydrocortisone Cream)

Anusol Hc Professional Information


The following local adverse reactions are reported infrequently with topical corticosteroids, but may occur more frequently with the use of occlusive dressings. These reactions are listed in an approximate decreasing order of occurrence:

Acneiform eruptions
Perioral dermatitis
Allergic contact dermatitis
Maceration of the skin
Secondary infection
Skin atrophy

Read the entire FDA prescribing information for Anusol Hc (Hydrocortisone Cream)

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© Anusol Hc Patient Information is supplied by Cerner Multum, Inc. and Anusol Hc Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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