Appetite Stimulants Drug Class

Reviewed on 12/29/2022

What Is the Function, How Do Appetite Stimulants Work?

Appetite stimulants are medications prescribed to increase appetite and improve the nutritional status of patients experiencing severe weight loss associated with certain chronic illnesses. The FDA-approved appetite stimulant is megestrol acetate, a progestin, which is a synthetic derivative of progesterone, the natural female sex hormone.

Megestrol acetate was originally developed as a contraceptive, but the side effect of weight gain led to its use as an appetite stimulant. Megestrol acetate prevents ovulation and the release of estrogen from the ovaries and is also used in palliative care for advanced stages of endometrial and breast cancers.

It is not clear how exactly megestrol increases appetite. Studies suggest that progesterone plays a major role in reducing inflammation and improving nutritional status in the late stages of pregnancy. It is believed that megestrol’s anti-inflammatory activity may be a reason for an increase in appetite, resultant weight gain, and improvement in quality of life.

Megestrol is thought to reduce inflammation by inhibiting the production of pro-inflammatory proteins (cytokines) such as tumor necrosis factor-a, interleukin-1, and interleukin-6. Megestrol may also stimulate the synthesis, release, and transport of neuropeptide Y, a peptide in the brain that stimulates appetite.

How Are Appetite Stimulants Used?

Appetite stimulants are oral tablets and suspensions used to stimulate appetite in the following conditions:


Off-label uses:

  • Cancer-related cachexia

What Are Side Effects of Appetite Stimulants?

Side effects of appetite stimulants may include the following:

Menstrual disorders such as:

Gastrointestinal issues such as:

  • Diarrhea
  • Flatulence
  • Indigestion
  • Nausea
  • Vomiting
  • Weight gain

Blood coagulation disorders such as:

Information contained herein is not intended to cover all possible side effects, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Check with your doctor or pharmacist to make sure these drugs do not cause any harm when you take them along with other medicines. Never stop taking your medication and never change your dose or frequency without consulting your doctor.

What Are Names of Some Appetite Stimulant Drugs?

Generic and brand names of appetite stimulant drugs include:


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