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Last reviewed on RxList: 9/9/2020
Apresoline Side Effects Center

What Is Apresoline?

Apresoline (hydralazine hydrochloride) is an antihypertensive drug indicated for treatment of hypertension by relaxing vascular smooth muscle. The brand name Apresoline is no longer available in the U.S. Generic versions may be available.

What Are Side Effects of Apresoline?

Common side effects of Apresoline (hydralazine hydrochloride) include:

Dosage for Apresoline

The initial dose of Apresoline is 10 mg four times daily for the first 2-4 days, increased to 25 mg four times daily for the balance of the first week. For the second and subsequent weeks, increase dosage of Apresoline to 50 mg four times daily. For maintenance, adjust dosage to the lowest effective levels.

What Drugs, Substances, or Supplements Interact with Apresoline?

Apresoline may interact with diazoxide or MAO inhibitors. Tell your doctor all medications and supplements you use.

Apresoline During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant during treatment with Apresoline; it may harm a fetus. Apresoline can pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.

Additional Information

Our Apresoline Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Apresoline Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • chest pain or pressure, pain spreading to your jaw or shoulder;
  • fast or pounding heartbeats;
  • a light-headed feeling, like you might pass out;
  • numbness, tingling, or burning pain in your hands or feet;
  • painful or difficult urination;
  • little or no urination; or
  • lupus-like syndrome--joint pain or swelling with fever, swollen glands, muscle aches, chest pain, vomiting, unusual thoughts or behavior, and patchy skin color.

Common side effects may include:

  • chest pain, fast heart rate;
  • headache; or
  • nausea, vomiting, diarrhea, loss of appetite.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Apresoline (Hydralazine)


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Apresoline Professional Information


Adverse reactions with Apresoline (hydralazine) are usually reversible when dosage is reduced. However, in some cases it may be necessary to discontinue the drug. The following adverse reactions have been observed, but there has not been enough systematic collection of data to support an estimate of their frequency.


Headache, anorexia, nausea, vomiting, diarrhea, palpitations, tachycardia, angina pectoris.

Less Frequent

Digestive: constipation, paralytic ileus.

Cardiovascular: hypotension, paradoxical pressor response, edema.

Respiratory: dyspnea.

Neurologic: peripheral neuritis evidenced by paresthesia, numbness, and tingling, dizziness: tremors; muscle cramps; psychotic reactions characterized by depression, disorientation, or anxiety.

Genitourinary: difficulty in urination.

Hematologic: blood dyscrasias, consisting of reduction in hemoglobin and red cell count, leukopenia, agranulocytosis, purpura, lymphadenopathy; splenomegaly.

Hypersensitive Reactions: rash, urticaria, pruritus, fever, chills, arthralgia, eosinophilia, and, rarely, hepatitis.

Other: nasal congestion, flushing, lacrimation, conjunctivitis.

Read the entire FDA prescribing information for Apresoline (Hydralazine)

Related Resources for Apresoline

Read the Apresoline User Reviews »

© Apresoline Patient Information is supplied by Cerner Multum, Inc. and Apresoline Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.


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