Artane

Last reviewed on RxList: 9/9/2020
Artane Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Artane?

Artane (trihexyphenidyl) is an antispasmodic drug used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease. Artane is also used to treat and prevent the same muscular conditions when they are caused by certain drugs.

What Are Side Effects of Artane?

Side effects of Artane include:

  • dry mouth,
  • nervousness,
  • drowsiness,
  • dizziness,
  • large pupils,
  • blurred vision,
  • difficulty urinating,
  • constipation,
  • nervousness,
  • anxiety,
  • decreased sweating,
  • flushing, or
  • upset stomach.

Dosage for Artane

As initial therapy for parkinsonism, a dose of 1 mg of Artane in tablet or elixir form may be administered the first day.

What Drugs, Substances, or Supplements Interact with Artane?

Artane may interact with alcohol, tricyclic antidepressants, phenothiazines, thiothixene, chlorprothixene, antihistamines (often found in prescription and over-the-counter cold, allergy, and sleep medicines), quinidine, amantadine, digoxin, or haloperidol. Tell your doctor all medications and supplements you use.

Artane During Pregnancy and Breastfeeding

It is not known whether trihexyphenidyl will be harmful to an unborn baby. It is also not known whether this drug is excreted in human milk. Consult your doctor before breastfeeding.

Additional Information

Our Artane Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

Parkinson's disease is only seen in people of advanced age. See Answer
Artane Consumer Information

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Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • blurred vision, tunnel vision, eye pain, or seeing halos around lights;
  • hot and dry skin, or a lack of sweating even if you feel hot;
  • rapid or jerky repetitive involuntary movement;
  • severe constipation;
  • painful or difficult urination;
  • unusual thoughts or behavior;
  • confusion, memory problems; or
  • severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.

Common side effects may include:

  • blurred vision;
  • dry mouth;
  • constipation, decreased urination;
  • dizziness, drowsiness, weakness;
  • nausea, vomiting;
  • headache; or
  • feeling restless or nervous.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Artane (Trihexyphenidyl)

SLIDESHOW

Dementia, Alzheimer's Disease, and Aging Brains See Slideshow
Artane Professional Information

SIDE EFFECTS

Minor side effects, such as dryness of the mouth, blurred vision, dizziness, mild nausea or nervousness, will be experienced by 30 to 50 percent of all patients. These sensations, however, are much less troublesome with ARTANE (trihexyphenidyl) than with belladonna alkaloids and are usually less disturbing than unallenated parkinsonism. Such reactions tend to become less pronounced, and even to disappear, as treatment continues. Even before these reactions have remitted spontaneously, they may often be controlled by careful adjustment of dosage form, amount of drug, or interval between doses.

Isolated instances of suppurative parotitis secondary to excessive dryness of the mouth, skin rashes, dilatation of the colon, paralytic ileus, and certain psychiatric manifestations such as delusions, hallucinations, and paranoia, all of which may occur with any of the atropine-like drugs, have been reported rarely with ARTANE® (trihexyphenidyl)

Potential side effects associated with the use of any atropine-like drugs, including Artane (trihexyphenidyl) , include cognitive dysfunctions, including confusion and memory impairment; constipation, drowsiness, urinary hesitancy or retention, tachycardia, dilation of the pupil, increased intraocular pressure, choreiform movements, weakness, vomiting, and headache. Exacerbation of parkinsonism with abrupt treatment withdrawal has been reported. Neuroleptic malignant syndrome with abrupt treatment withdrawal has been reported (see WARNINGS, Neuroleptic Malignant Syndrome).

The occurrence of angle-closure glaucoma in patients receiving trihexyphenidyl HCl has been reported (blindness has been reported in some cases). Paradoxical sinus bradycardia, dry skin, and cycloplegia have been reported.

In addition to adverse events seen in adults, the following adverse events have been reported in the literature in pediatric patients: hyperkinesia, psychosis, forgetfulness, weight loss, restlessness, chorea, and sleep alterations.

Drug Abuse And Dependence

Although ARTANE (trihexyphenidyl) is not classified as a controlled substance, the possibility of abuse should be borne in mind due to its stimulant and euphoriant properties.

Read the entire FDA prescribing information for Artane (Trihexyphenidyl)

© Artane Patient Information is supplied by Cerner Multum, Inc. and Artane Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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