Asparlas vs. Oncaspar

Reviewed on 6/2/2020

Are Asparlas and Oncaspar the Same Thing?

Asparlas (calaspargase pegol-mknl) and Oncaspar (pegaspargase) are anti-cancer (antineoplastic) drugs used to treat acute lymphoblastic leukemia.

Side effects of Asparlas and Oncaspar that are similar include diarrhea.

Side effects of Asparlas that are different from Oncaspar include elevated transaminase, increased bilirubin, pancreatitis, abnormal clotting studies, hypersensitivity, shortness of breath, bleeding, pneumonia, and abnormal heart rate.

Side effects of Oncaspar that are different from Asparlas include nausea, vomiting, weakness, loss of appetite, dizziness, skin rash or itching, depression, drowsiness, swelling in your hands/ankles/feet, weight loss, stomach cramps, headache, tiredness, irritability, and injection site reactions (pain, swelling, or redness).

Asparlas may interact with oral contraceptives.

Oncaspar may interact with vincristine, prednisone, and methotrexate.

What Are Possible Side Effects of Asparlas?

Side effects of Asparlas include:

  • elevated transaminase,
  • bilirubin increased,
  • pancreatitis,
  • abnormal clotting studies,
  • diarrhea,
  • hypersensitivity,
  • shortness of breath,
  • bleeding,
  • pneumonia, and
  • abnormal heart rate

This is not a complete list of side effects, and others may occur.

What Are Possible Side Effects of Oncaspar?

Common side effects of Oncaspar include:

  • nausea
  • vomiting
  • weakness
  • loss of appetite
  • diarrhea
  • dizziness
  • skin rash or itching
  • depression
  • drowsiness
  • swelling in your hands/ankles/feet
  • weight loss
  • stomach cramps
  • headache
  • tiredness
  • irritability
  • injection site reactions (pain swelling or redness).

What is Asparlas?

Asparlas (calaspargase pegol - mknl) is an asparagine specific enzyme indicated as a component of a multi-agent chemotherapeutic regimen for the treatment of acute lymphoblastic leukemia in pediatric and young adult patients age 1 month to 21 years.

What is Oncaspar?

Oncaspar (pegaspargase) is a cancer (antineoplastic) medication used to treat acute lymphoblastic leukemia.

What Drugs Interact With Asparlas?

Asparlas may interact with oral contraceptives. Tell your doctor all medications and supplements you use.

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What Drugs Interact With Oncaspar?

Oncaspar may interact with vincristine, prednisone, or methotrexate. Tell your doctor all medications and supplements you use.

How Should Asparlas be Taken?

The recommended dosage of Asparlas is 2,500 units/m2 intravenously no more frequently than every 21 days.

How Should Oncaspar be Taken?

The recommended dose of Oncaspar is 2,500 IU/m2 intramuscularly (IM) or intravenously (IV). It should be administered no more frequently than every 14 days.

Disclaimer

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References


Asparlas Product Information.

http://asparlas.com/

Oncaspar Product Information.

https://www.oncaspar.com/

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