Aspirin Rectal

What Is Aspirin Rectal Used For and How Does it Work?

Aspirin rectal is an over-the-counter (OTC) product used as a fever reducer/pain reliever (antipyretic/analgesic).

Aspirin rectal is available under the following different brand names: N/A.

What Are the Dosages of Aspirin Rectal?

Dosages of Aspirin Rectal:

Dosage Forms and Strengths


  • 60mg
  • 120mg
  • 200mg
  • 300mg
  • 600mg

Dosage Considerations – Should be Given as Follows:


  • Adults and children over 12 years: 300-600 mg rectally every 4-6 hours as needed
  • Children under 12 years: 10-15 mg/kg/dose rectally every 4-6 hours; not to exceed 4 g/day


  • Aspirin Rectal 180 mg orally 2 hours before chemotherapy PLUS
  • Dexamethasone 20 mg orally 30 minutes before chemotherapy PLUS
  • 5HT-3 antagonist according to the manufacturer’s prescribing information

The patient should lie on the left side with knees bent

  • Remove protective wrap before inserting
  • Gently insert the tip into the rectum with slight side-to-side movement (tip of suppository pointing toward navel)

Renal Impairment

  • CrCl less than 10 mL: Not recommended

Hepatic Impairment

  • Not recommended

What Are Side Effects Associated with Using Aspirin Rectal?

Common side effects of aspirin rectal include:

Other side effects of aspirin rectal include:

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

What Other Drugs Interact with Aspirin Rectal?

If your doctor has directed you to use this medication, your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor, health care provider or pharmacist first.

  • Severe interactions of aspirin_rectal include:
  • Aspirin Rectal has serious interactions with at least 27 different drugs.
  • Aspirin Rectal has moderate interactions with at least 76 different drugs.
  • Mild interactions of aspirin_rectal include:

What Are Warnings and Precautions for Aspirin Rectal?


This medication contains aspirin rectal. Do not take aspirin rectal if you are allergic to aspirin rectal or any ingredients contained in this drug.


  • Hypersensitivity to aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs)
  • Hepatitis or severe hepatic/renal impairment
  • Do not use in children or adolescents with viral infections (e.g., influenza, chickenpox) because of the risk of Reye syndrome

Effects of Drug Abuse

  • No information is available.

Short-Term Effects

  • See "What Are Side Effects Associated with Using Aspirin Rectal?"

Long-Term Effects

  • See "What Are Side Effects Associated with Using Aspirin Rectal?"


  • Many dosage forms, check the label carefully!
  • Gastrointestinal bleeding; particular caution in patients with a history of gastrointestinal bleed, alcoholism, or bleeding disorders
  • Avoid with active peptic ulcer disease
  • Avoid severe renal impairment (i.e., CrCl less than 10 mL/min)
  • Avoid severe hepatic impairment

Pregnancy and Lactation

  • Use aspirin rectal during pregnancy only in LIFE-THREATENING emergencies when no safer drug is available. There is positive evidence of human fetal risk. Avoid the use of aspirin rectal during pregnancy, particularly in the third trimester because of the risk for premature closure of the ductus arteriosus.
  • Aspirin rectal is excreted in breast milk. Do not breastfeed while using aspirin rectal.
  • Pregnant or breastfeeding patients should seek the advice of a health professional before using over-the-counter (OTC) drugs.

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