Atripla vs. Genvoya, Stribild

Reviewed on 11/11/2019

Are Genvoya, Stribild and Atripla the Same Thing?

Atripla (efavirenz/emtricitabine/tenofovir disoproxil fumarate) and Genvoya (elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide) are combinations of antiviral medications used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS).

Side effects of Atripla and Genvoya that are similar include tiredness/fatigue, headache, nausea, diarrhea, and changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

Side effects of Atripla that are different from Genvoya include dizziness, trouble sleeping, drowsiness, unusual dreams, trouble concentrating, vomiting, gas, upset stomach, and skin discoloration (such as small spots/freckles, darkening of the palms of the hands/soles of the feet).

Both Atripla and Genvoya may interact with other antiretroviral medications, seizure medicines, cholesterol medications (“statins”), and other HIV medicines.

Atripla may also interact with sertraline, methadone, blood thinners, antibiotics, and calcium channel blockers.

Genvoya may also interact with drugs metabolized by CYP3A or CYP2D6, alpha 1-adrenoreceptor antagonists, antimycobacterials, ergot derivatives, St. John's wort, cisapride, pimozide, sildenafil, and sedative/hypnotics.

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What Are Possible Side Effects of Atripla?

Common side effects of Atripla include:

  • dizziness,
  • trouble sleeping,
  • drowsiness,
  • unusual dreams, and
  • trouble concentrating.

Side effects may begin 1-2 days after starting Atripla and usually go away in 2-4 weeks. Other side effects of Atripla include:

  • tiredness,
  • headache,
  • nausea,
  • vomiting,
  • gas,
  • upset stomach,
  • diarrhea, and
  • skin discoloration (such as small spots/freckles, darkening of the palms of the hands/soles of the feet), and
  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

Tell your doctor if you have serious side effects of Atripla including:

  • unexplained weight loss,
  • persistent muscle aches or weakness,
  • joint pain,
  • numbness or tingling of the hands/feet/arms/legs,
  • severe tiredness,
  • vision changes,
  • severe or persistent headaches,
  • signs of infection (such as fever, chills, trouble breathing, cough, non-healing skin sores),
  • signs of an overactive thyroid (such as irritability, nervousness, heat intolerance, fast/pounding/irregular heartbeat, bulging eyes, unusual growth in the neck or thyroid known as a goiter), or
  • signs of a certain nerve problem known as Guillain-Barre Syndrome (such as difficulty breathing/swallowing/moving your eyes, drooping face, paralysis, slurred speech).

What Are Possible Side Effects of Genvoya, Stribild?

Common side effects of Genvoya, Stribild include:

  • nausea,
  • diarrhea,
  • fatigue,
  • headache, and
  • body fat redistribution.

Serious side effects of Genvoya include lactic acidosis. Tell your doctor if you have symptoms of lactic acidosis such as weakness, unusual muscle pain, difficulty breathing, feeling cold in the extremities, dizziness, lightheadedness, or fast or irregular heartbeat.

What Is Atripla?

Atripla (efavirenz/emtricitabine/tenofovir disoproxil fumarate) is an antiviral medication that treats HIV, which causes acquired immunodeficiency syndrome (AIDS). Atripla is not a cure for HIV or AIDS.

What Is Genvoya, Stribild?

Genvoya, Stribild (elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide) is a four-drug combination of an HIV-1 integrase strand transfer inhibitor (INSTI), a CYP3A inhibitor, and two HIV-1 nucleoside analog reverse transcriptase inhibitors (NRTIs) and is indicated as a complete regimen for the treatment of HIV-1 infection in adults and pediatric patients 12 years of age and older who have no antiretroviral treatment history or to replace the current antiretroviral regimen in those who are virologically-suppressed (HIV-1 RNA less than 50 copies per mL) on a stable antiretroviral regimen for at least 6 months with no history of treatment failure and no known substitutions associated with resistance to the individual components of Genvoya.

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What Drugs Interact With Atripla?

Atripla may interact with acyclovir, ganciclovir, valacyclovir, valganciclovir, sertraline, methadone, adefovir, cidofovir, blood thinners, cholesterol medications, antibiotics, calcium channel blockers, seizure medicines, or other HIV medicines. Tell your doctor all medications you use. Atripla is not recommended for use during pregnancy. It may harm a fetus, especially if taken during the first 3 months of pregnancy. Women of childbearing age should have a pregnancy test before starting Atripla. Consult your doctor about using 2 forms of birth control (such as condoms with birth control pills) during treatment and for 3 months after the end of treatment. Atripla decreases effectiveness of hormonal birth control, so barrier protection must be used. If you become pregnant or think you may be pregnant, tell your doctor. Discuss other HIV treatment options during pregnancy to decrease risk of HIV transmission to the baby. It is unknown if this medication passes into breast milk. Because breast milk can transmit HIV, do not breastfeed.

What Drugs Interact With Genvoya, Stribild?

Genvoya, Stribild may interact with other antiretroviral medications, drugs metabolized by CYP3A or CYP2D6, alpha 1-adrenoreceptor antagonists, anticonvulsants, antimycobacterials, ergot derivatives, St. John's wort, cisapride, HMG-CoA reductase inhibitors, pimozide, sildenafil, and sedative/hypnotics. Tell your doctor all medications and supplements you use. During pregnancy, Genvoya should be used only if prescribed. Tell your doctor if you are pregnant before taking Genvoya. Women infected with HIV should not breastfeed due to the potential for HIV transmission.

How Should Atripla Be Taken?

The adult dose of Atripla is one tablet once daily taken orally on an empty stomach. Dosing at bedtime may improve the tolerability of nervous system symptoms.

How Should Genvoya, Stribild Be Taken?

The recommended dosage of Genvoya, Stribild is one tablet taken orally once daily with food. Prior to taking Genvoya, patients should be tested for hepatitis B infection.

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References
Gilead. Atripla Prescribing Information.

https://www.atripla.com/

Gilead. Genvoya Product Information.

https://www.genvoya.com

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