Medical Editor: John P. Cunha, DO, FACOEP
Atropine (atropine sulfate) Ophthalmic Solution is topical anticholinergic for ophthalmic use indicated for cycloplegia, mydriasis, and penalization of the healthy eye in the treatment of amblyopia. Common side effects of Atropine Ophthalmic Solution include
- eye sensitivity to light,
- increased blood pressure,
- eye pain and stinging upon instillation of drops,
- blurred vision,
- eye inflammation (superficial keratitis) and decreased tearing,
- contact dermatitis,
- eyelid swelling,
- skin dryness,
- dry mouth and throat,
- delirium from stimulation of the central nervous system,
- fast heart rate, and
- flushed skin of the face and neck.
In individuals from three (3) months of age or greater, the dose of Atropine Ophthalmic Solution is 1 drop applied topically to the cul-de-sac of the conjunctiva, forty minutes prior to the intended maximal dilation time. In individuals 3 years of age or greater, doses may be repeated up to twice daily as needed. Atropine Ophthalmic Solution may interact with monoamine oxidase inhibitors (MAOIs). Tell your doctor all medications and supplements you use. During pregnancy Atropine Ophthalmic Solution should be used only if prescribed; it is unknown if it would affect a fetus. Traces of Atropine Ophthalmic Solution pass into breast milk. Consult your doctor before breastfeeding.
Our Atropine (atropine sulfate) Ophthalmic Solution Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
The following serious adverse reactions are described below and elsewhere in the labeling:
- Photophobia and Blurred Vision [See WARNINGS AND PRECAUTIONS]
- Elevation in Blood Pressure [See WARNINGS AND PRECAUTIONS]
The following adverse reactions have been identified following use of atropine sulfate ophthalmic solution. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Ocular Adverse Reactions
Eye pain and stinging occurs upon instillation of atropine sulfate ophthalmic solution. Other commonly occurring adverse reactions include, blurred vision, photophobia, superficial keratitis and decreased lacrimation. Allergic reactions such as papillary conjunctivitis, contact dermatitis, and lid edema may also occur less commonly.
Systemic Adverse Reactions
Systemic effects of atropine are related to its anti-muscarinic activity. Systemic adverse events reported include dryness of skin, mouth, and throat from decreased secretions from mucus membranes; restlessness, irritability or delirium from stimulation of the central nervous system; tachycardia; flushed skin of the face and neck.
Read the entire FDA prescribing information for Atropine Solution (atropine sulfate)