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Augmentin ES

Last reviewed on RxList: 10/6/2020
Augmentin ES Side Effects Center

What Is Augmentin ES?

Augmentin ES 600 (amoxicillin/clavulanate potassium) is a combination of a penicillin-type antibiotic and a form of clavulanic acid, a beta-lactamase inhibitor, used to treat many different infections caused by bacteria, such as sinusitis, pneumonia, ear infections, bronchitis, urinary tract infections, and infections of the skin. Augmentin ES is available in generic form.

What Are Side Effects of Augmentin ES?

Common side effects of Augmentin ES include:

Tell the doctor if you have rare but serious side effects of Augmentin ES including:

  • dark urine,
  • persistent nausea or vomiting,
  • severe stomach or abdominal pain,
  • yellowing eyes or skin,
  • easy bruising or bleeding,
  • new signs of infection (such as fever, persistent sore throat), or
  • unusual tiredness.

Dosage for Augmentin ES?

Dosage of Augmentin ES for pediatric patients 3 months and older: based on the amoxicillin component (600 mg/5 mL), the recommended dose is 90 mg/kg/day divided every 12 hours, administered for 10 days.

What Drugs, Substances, or Supplements Interact with Augmentin ES?

Augmentin ES may interact with allopurinol, probenecid, or other antibiotics. Tell your doctor all medications you are taking.

Augmentin ES During Pregnancy and Breastfeeding

During pregnancy, Augmentin ES should be used only when prescribed. This medication passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Augmentin ES 600 (amoxicillin/clavulanate potassium) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Augmentin ES Consumer Information

Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);
  • pale or yellowed skin, dark colored urine, fever, confusion or weakness;
  • loss of appetite, upper stomach pain;
  • little or no urination; or
  • easy bruising or bleeding.

Common side effects may include:

  • nausea, vomiting; diarrhea;
  • rash, itching;
  • vaginal itching or discharge; or
  • diaper rash.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Augmentin ES (Amoxicillin Clavulanate Potassium)

QUESTION

Bowel regularity means a bowel movement every day. See Answer
Augmentin ES Professional Information

SIDE EFFECTS

AUGMENTIN ES-600 is generally well tolerated. The majority of side effects observed in pediatric clinical trials of acute otitis media were either mild or moderate, and transient in nature; 4.4% of patients discontinued therapy because of drug-related side effects. The most commonly reported side effects with probable or suspected relationship to AUGMENTIN ES-600 were contact dermatitis, i.e., diaper rash (3.5%), diarrhea (2.9%), vomiting (2.2%), moniliasis (1.4%), and rash (1.1%). The most common adverse experiences leading to withdrawal that were of probable or suspected relationship to AUGMENTIN ES-600 were diarrhea (2.5%) and vomiting (1.4%).

The following adverse reactions have been reported for ampicillin-class antibiotics:

Gastrointestinal

Diarrhea, nausea, vomiting, indigestion, gastritis, stomatitis, glossitis, black “hairy” tongue, mucocutaneous candidiasis, enterocolitis, and hemorrhagic/pseudomembranous colitis. Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment. (See WARNINGS.)

Hypersensitivity Reactions

Skin rashes, pruritus, urticaria, angioedema, serum sickness– like reactions (urticaria or skin rash accompanied by arthritis, arthralgia, myalgia, and frequently fever), erythema multiforme (rarely Stevens-Johnson syndrome), acute generalized exanthematous pustulosis, hypersensitivity vasculitis, and an occasional case of exfoliative dermatitis (including toxic epidermal necrolysis) have been reported. These reactions may be controlled with antihistamines and, if necessary, systemic corticosteroids. Whenever such reactions occur, the drug should be discontinued, unless the opinion of the physician dictates otherwise. Serious and occasional fatal hypersensitivity (anaphylactic) reactions can occur with oral penicillin. (See WARNINGS.)

Liver

A moderate rise in AST (SGOT) and/or ALT (SGPT) has been noted in patients treated with ampicillin-class antibiotics, but the significance of these findings is unknown. Hepatic dysfunction, including hepatitis and cholestatic jaundice, (See CONTRAINDICATIONS.), increases in serum transaminases (AST and/or ALT), serum bilirubin, and/or alkaline phosphatase, has been infrequently reported with AUGMENTIN. It has been reported more commonly in the elderly, in males, or in patients on prolonged treatment. The histologic findings on liver biopsy have consisted of predominantly cholestatic, hepatocellular, or mixed cholestatic-hepatocellular changes. The onset of signs/symptoms of hepatic dysfunction may occur during or several weeks after therapy has been discontinued. The hepatic dysfunction, which may be severe, is usually reversible. On rare occasions, deaths have been reported (less than 1 death reported per estimated 4 million prescriptions worldwide). These have generally been cases associated with serious underlying diseases or concomitant medications.

Renal

Interstitial nephritis and hematuria have been reported rarely. Crystalluria has also been reported (see OVERDOSAGE).

Hemic and Lymphatic Systems

Anemia, including hemolytic anemia, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia, and agranulocytosis have been reported during therapy with penicillins. These reactions are usually reversible on discontinuation of therapy and are believed to be hypersensitivity phenomena. A slight thrombocytosis was noted in less than 1% of the patients treated with AUGMENTIN. There have been reports of increased prothrombin time in patients receiving AUGMENTIN and anticoagulant therapy concomitantly.

Central Nervous System

Agitation, anxiety, behavioral changes, confusion, convulsions, dizziness, insomnia, and reversible hyperactivity have been reported rarely.

Miscellaneous

Tooth discoloration (brown, yellow, or gray staining) has been rarely reported. Most reports occurred in pediatric patients. Discoloration was reduced or eliminated with brushing or dental cleaning in most cases.

Read the entire FDA prescribing information for Augmentin ES (Amoxicillin Clavulanate Potassium)

Related Resources for Augmentin ES

Read the Augmentin ES User Reviews »

© Augmentin ES Patient Information is supplied by Cerner Multum, Inc. and Augmentin ES Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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