Last updated on RxList: 4/12/2021
Auvi-Q Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Auvi-Q?

Auvi-Q (epinephrine) Injection is a sympathomimetic catecholamine used in the emergency treatment of allergic reactions or anaphylaxis, which can be caused by stings or bites from insects (such as bees, wasps, hornets, yellow jackets, fire ants, and mosquitos), food, drugs, diagnostic testing substances, idiopathic (unknown) cause, or induced by exercise.

What Are Side Effects of Auvi-Q?

Common side effects of Auvi-Q injection include:

  • anxiety
  • apprehensiveness
  • nervousness
  • restlessness
  • tremor or shakiness
  • weakness
  • dizziness
  • sweating
  • increased heart rate
  • heart palpitations
  • irregular heartbeat
  • pale skin (pallor)
  • nausea and vomiting
  • headache
  • difficulty breathing, and
  • injection site reactions (redness, bruising, bleeding, discoloration).

Tell your doctor if you have serious side effects of Auvi-Q injection such as arrhythmias, including fatal ventricular fibrillation.

Dosage for Auvi-Q

If you are 66 pounds or heavier the recommended dosage of Auvi-Q is 0.3 mg, and 0.15 mg if you are 33 to 66 pounds. Auvi-Q should be used in addition to immediate medical care. Do not inject Auvi-Q intravenously, into the buttock or fingers, hands or feet. Although Auvi-Q contains sulfite you can still use Auvi-Q if you are sulfite sensitive. Caution should be used if you have heart disease, cardiac arrhythmias, coronary artery or organic heart disease, hypertension, hyperthyroidism, diabetes, and elderly individuals.

What Drugs, Substances, or Supplements Interact with Auvi-Q?

Auvi-Q may interact with cardiac glycosides, diuretics, anti-arrhythmics, antidepressants, monoamine oxidase inhibitors, levothyroxine sodium, antihistamines, beta-blockers, alpha blockers, or ergot alkaloids. Tell your doctor all medications you use.

Auvi-Q During Pregnancy and Breastfeeding

Caution should also be taken if you are pregnant or breastfeeding.

Additional Information

Our Auvi-Q (epinephrine) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Could I Be Allergic? Discover Your Allergy Triggers See Slideshow
Auvi-Q Consumer Information

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Before using epinephrine, tell your doctor if any past use of this medicine caused an allergic reaction to get worse.

Call your doctor at once if you notice pain, swelling, warmth, redness, or other signs of infection around the area where you gave an injection.

Common side effects may include:

  • breathing problems;
  • fast, irregular, or pounding heartbeats;
  • pale skin, sweating;
  • nausea and vomiting;
  • dizziness;
  • weakness or tremors;
  • headache; or
  • feeling restless, fearful, nervous, anxious, or excited.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Auvi-Q (Epinephrine Injection)


Allergies can best be described as: See Answer
Auvi-Q Professional Information


Due to lack of randomized, controlled clinical trials of epinephrine for the treatment of anaphylaxis, the true incidence of adverse reactions associated with the systemic use of epinephrine is difficult to determine. Adverse reactions reported in observational trials, case reports, and studies are listed below.

Common adverse reactions to systemically administered epinephrine include anxiety; apprehensiveness; restlessness; tremor; weakness; dizziness; sweating; palpitations; pallor; nausea and vomiting; headache; and/or respiratory difficulties. These symptoms occur in some persons receiving therapeutic doses of epinephrine, but are more likely to occur in patients with hypertension or hyperthyroidism [see WARNINGS AND PRECAUTIONS].

Arrhythmias, including fatal ventricular fibrillation, have been reported, particularly in patients with underlying cardiac disease or those receiving certain drugs [see WARNINGS AND PRECAUTIONS and DRUG INTERACTIONS].

Rapid rises in blood pressure have produced cerebral hemorrhage, particularly in elderly patients with cardiovascular disease [see WARNINGS AND PRECAUTIONS].

Angina may occur in patients with coronary artery disease [see WARNINGS AND PRECAUTIONS].

Rare cases of stress cardiomyopathy have been reported in patients treated with epinephrine.

Accidental injection into the digits, hands or feet may result in loss of blood flow to the affected area [see WARNINGS AND PRECAUTIONS].

Adverse events experienced as a result of accidental injections may include increased heart rate, local reactions including injection site pallor, coldness and hypoesthesia or injury at the injection site resulting in bruising, bleeding, discoloration, erythema or skeletal injury.

Injection of epinephrine into the buttock has resulted in cases of gas gangrene [see WARNINGS AND PRECAUTIONS].

Rare cases of serious skin and soft tissue infections, including necrotizing fasciitis and myonecrosis caused by Clostridia (gas gangrene), have been reported at the injection site following epinephrine injection in the thigh [see WARNINGS AND PRECAUTIONS].


Patients who receive epinephrine while concomitantly taking cardiac glycosides, diuretics, or anti-arrhythmics should be observed carefully for the development of cardiac arrhythmias [see WARNINGS AND PRECAUTIONS].

The effects of epinephrine may be potentiated by tricyclic antidepressants, monoamine oxidase inhibitors, levothyroxine sodium, and certain antihistamines, notably chlorpheniramine, tripelennamine, and diphenhydramine.

The cardiostimulating and bronchodilating effects of epinephrine are antagonized by beta-adrenergic blocking drugs, such as propranolol.

The vasoconstricting and hypertensive effects of epinephrine are antagonized by alpha-adrenergic blocking drugs, such as phentolamine.

Ergot alkaloids may also reverse the pressor effects of epinephrine.

Read the entire FDA prescribing information for Auvi-Q (Epinephrine Injection)

© Auvi-Q Patient Information is supplied by Cerner Multum, Inc. and Auvi-Q Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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