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Avalide

Last reviewed on RxList: 9/24/2018
Avalide Patient Information Including Side Effects

Brand Names: Avalide

Generic Name: hydrochlorothiazide and irbesartan

What is hydrochlorothiazide and irbesartan (Avalide)?

Hydrochlorothiazide and irbesartan is a combination medicine used to treat high blood pressure (hypertension).

Hydrochlorothiazide and irbesartan contains a diuretic (water pill) and an angiotensin II receptor blocker (ARB).

Hydrochlorothiazide and irbesartan may also be used for purposes not listed in this medication guide.

What are the possible side effects of hydrochlorothiazide and irbesartan (Avalide)?

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

In rare cases, this medicine can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.

Also call your doctor at once if you have:

  • eye pain, vision problems;
  • a light-headed feeling, like you might pass out;
  • little or no urinating;
  • jaundice (yellowing of the skin or eyes);
  • easy bruising, unusual bleeding; or
  • signs of an electrolyte imbalance--increased thirst or urination, confusion, vomiting, constipation, muscle pain or weakness, leg cramps, bone pain, lack of energy, irregular heartbeats, tingly feeling.

Common side effects may include:

  • dizziness;
  • muscle or joint pain; or
  • feeling tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What is the most important information I should know about hydrochlorothiazide and irbesartan (Avalide)?

Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away.

You should not use this medicine if you are unable to urinate, or if you are allergic to sulfa drugs.

If you have diabetes, do not use hydrochlorothiazide and irbesartan together with any medication that contains aliskiren (a blood pressure medicine).

SLIDESHOW

How to Lower Blood Pressure: Exercise Tips See Slideshow
Avalide Patient Information including How Should I Take

What should I discuss with my healthcare provider before taking hydrochlorothiazide and irbesartan (Avalide)?

You should not use this medicine if you are allergic to irbesartan or hydrochlorothiazide, or if:

  • you are unable to urinate; or
  • you are allergic to sulfa drugs.

If you have diabetes, do not use hydrochlorothiazide and irbesartan together with any medication that contains aliskiren (a blood pressure medicine).

You may also need to avoid taking hydrochlorothiazide and irbesartan with aliskiren if you have kidney disease.

Tell your doctor if you have ever had:

Do not use if you are pregnant, and tell your doctor right away if you become pregnant. Hydrochlorothiazide and irbesartan can cause injury or death to the unborn baby if you take this medicine during your second or third trimester.

You should not breast-feed while using this medicine.

How should I take hydrochlorothiazide and irbesartan (Avalide)?

Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.

You may take this medicine with or without food.

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medication, which can lead to severely low blood pressure or a serious electrolyte imbalance.

Your blood pressure will need to be checked often. Your blood and urine may also be tested if you have been vomiting or are dehydrated.

If you need surgery or medical tests, tell the surgeon ahead of time that you are using hydrochlorothiazide and irbesartan.

It may take up to 4 weeks for this medication to control your blood pressure. Keep using this medicine as directed, even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.

Store at room temperature away from moisture and heat.

QUESTION

Salt and sodium are the same. See Answer
Avalide Patient Information including If I Miss a Dose

What happens if I miss a dose (Avalide)?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose (Avalide)?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include fast or slow heartbeat, feeling light-headed, or fainting.

What should I avoid while taking hydrochlorothiazide and irbesartan (Avalide)?

If you also take cholestyramine or colestipol, avoid taking these medications within 4 hours before or 4 hours after you take hydrochlorothiazide and irbesartan.

Drinking alcohol can further lower your blood pressure and may cause side effects.

Do not use potassium supplements or salt substitutes, unless your doctor has told you to.

What other drugs will affect hydrochlorothiazide and irbesartan (Avalide)?

Tell your doctor about all your other medicines, especially:

This list is not complete. Other drugs may affect hydrochlorothiazide and irbesartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Where can I get more information (Avalide)?

Your pharmacist can provide more information about hydrochlorothiazide and irbesartan.


Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

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