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Axid vs. Pepcid

Reviewed on 10/22/2019

Are Axid and Pepcid the Same Thing?

Axid (nizatidine capsules) and Pepcid (famotidine) are H2-blockers used to treat duodenal ulcers.

Pepcid is also used to manage heartburn, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome.

Pepcid is available over-the-counter (OTC) as a generic.

Side effects of Axid and Pepcid that are similar include headache, dizziness, and diarrhea.

Side effects of Axid that are different from Pepcid include rash, runny or stuffy nose, sore throat, and cough.

Side effects of Pepcid that are different from Axid include constipation, fatigue, weakness, mood changes, insomnia, muscle pain or cramps, joint pain, dry mouth, nausea, and vomiting.

Both Axid and Pepcid may interact with alcohol, other stomach acid reducers, and aspirin.

Pepcid may also interact with atazanavir, itraconazole, ketoconazole, cefditoren, dasatinib, delavirdine, and fosamprenavir.

What Are Possible Side Effects of Axid?

Common side effects of Axid include:

  • headache,
  • dizziness,
  • rash,
  • diarrhea,
  • runny or stuffy nose,
  • sore throat, or
  • cough.

Contact your doctor if you experience serious side effects of Axid including:

What Are Possible Side Effects of Pepcid?

Common side effects of Pepcid include:

  • constipation,
  • diarrhea,
  • fatigue,
  • dizziness,
  • weakness,
  • mood changes,
  • headache,
  • insomnia,
  • muscle pain or cramps,
  • joint pain,
  • dry mouth,
  • nausea, or
  • vomiting.

What Is Axid?

Axid (nizatidine) Capsules are a histamine antagonist indicated for up to 8 weeks treatment of active duodenal ulcer. In most patients, the ulcer will heal within 4 weeks. Axid is available in generic form.

What Is Pepcid?

Pepcid (famotidine) is an H2-blocker used to treat and prevent recurrence of stomach and duodenal ulcers. Pepcid is also useful in managing heartburn, gastroesophageal reflux disease and Zollinger-Ellison syndrome. Pepcid is available as a generic drug.


Digestive Disorders: Common Misconceptions See Slideshow

What Drugs Interact With Axid?

Axid may interact with aspirin, alcohol, cimetidine, ranitidine, or famotidine. Tell your doctor all medications and supplements you use. There are no adequate and well-controlled studies in pregnant women. This drug should be used during pregnancy only if clearly needed. Axid can pass into breast milk and may harm a nursing baby. Breastfeeding while taking Axid is not recommended. The safety and effectiveness of Axid has not been determined for the pediatric population.

What Drugs Interact With Pepcid?

Pepcid may interact with atazanavir, itraconazole, ketoconazole, or aspirin or other NSAIDs (nonsteroidal anti-inflammatory drugs). Tell your doctor all medications and supplements you use.

How Should Axid Be Taken?

Axid is available in pulvules in strengths of 150 and 300mg; dosage is determined by the severity of the disease being treated. Prior to treatment, care should be taken to exclude the possibility of malignant gastric ulceration.

How Should Pepcid Be Taken?

Pepcid (famotidine) dosage depends on the condition being treated.


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Any drug information published on regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. assumes no responsibility for any healthcare administered to a person based on the information found on this site.

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Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the or websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.

FDA. Axid Drug Information.

McNeil Consumer Pharmaceuticals Co. Pepcid Product Information.

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