Aygestin vs. Provera

Are Aygestin and Provera the Same Thing?

Aygestin (norethindrone) and Provera (medroxyprogesterone) are forms of the female hormone progesterone used for birth control (contraception) to prevent pregnancy, and to treat menstrual disorders.

Aygestin is also used to treat endometriosis, abnormal vaginal bleeding caused by a hormone imbalance, and to prevent endometrial hyperplasia in postmenopausal women who have not undergone a hysterectomy and are receiving conjugated estrogens.

Provera is also used to treat endometrial or renal cancer.

What Are Possible Side Effects of Aygestin?

Common side effects of Aygestin include:

Tell your doctor if you have serious side effects of Aygestin including:

  • changes in vaginal bleeding (e.g., spotting, breakthrough bleeding, changes in menstrual flow, no menstrual bleeding),
  • depression,
  • swelling of the hands or feet,
  • frequent/burning/painful urination, or
  • yellowing eyes or skin.

What Are Possible Side Effects of Provera?

Common side effects of Provera include:

  • breast tenderness or discharge,
  • hives,
  • itching,
  • skin rash,
  • increased acne,
  • hair growth,
  • loss of scalp hair,
  • spotting or break-through bleeding,
  • changes in menstrual periods,
  • vaginal itching or discharge,
  • changes in appetite,
  • increased or decreased weight,
  • nausea,
  • stomach pain,
  • bloating,
  • fever,
  • sleep problems (insomnia), and
  • jaundice (yellowing of the skin or eyes), or
  • skin color changes.

Provera may increase risk of heart attacks, stroke, breast cancer, blood clots, and pulmonary emboli in postmenopausal women.

The dose of Provera varies depending on the indication.

What is Aygestin?

Aygestin (norethindrone) is a form of progesterone, a female hormone, used for birth control (contraception) to prevent pregnancy. Aygestin is also used to treat menstrual disorders, endometriosis, or abnormal vaginal bleeding caused by a hormone imbalance.

What is Provera?

Provera (medroxyprogesterone) is a form of the female hormone progesterone used to treat secondary amenorrhea; abnormal bleeding from the uterus due to hormonal imbalance and not due to fibroids, or cancer; and to prevent endometrial hyperplasia in postmenopausal women who have not undergone a hysterectomy and are receiving conjugated estrogens. Provera is used for contraception and for treating endometrial or renal cancer.


What is pelvic inflammatory disease (PID)? See Answer

What Drugs Interact With Aygestin?

Aygestin may interact with griseofulvin, rifampin, St. John's wort, ketoconazole or itraconazole, barbiturates, or HIV medicines. Tell your doctor all medications you are taking. Smoking combined with this medication increases your risk for strokes, blood clots, high blood pressure, and heart attacks. Aygestin must not be used during pregnancy because it may harm a fetus, especially during the first 4 months of pregnancy. This drug passes into breast milk.

What Drugs Interact With Provera?

Provera inhibits fertility at high doses. Provera may interact with other drugs. Tell your doctor all medications and supplements you use.

How Should Aygestin Be Taken?

The dosage and the duration of treatment with Aygestin is based on the patient's medical condition and response to therapy. Follow doctor's instructions. Withdrawal bleeding usually occurs within three to seven days after discontinuing Aygestin therapy.

How Should Provera Be Taken?

The dosage of Provera depends on the condition for which is has been prescribed.


Pelvic Pain: What's Causing Your Pelvic Pain? See Slideshow

All drug information provided on RxList.com is sourced directly from drug monographs published by the U.S. Food and Drug Administration (FDA).

Any drug information published on RxList.com regarding general drug information, drug side effects, drug usage, dosage, and more are sourced from the original drug documentation found in its FDA drug monograph.

Drug information found in the drug comparisons published on RxList.com is primarily sourced from the FDA drug information. The drug comparison information found in this article does not contain any data from clinical trials with human participants or animals performed by any of the drug manufacturers comparing the drugs.

The drug comparisons information provided does not cover every potential use, warning, drug interaction, side effect, or adverse or allergic reaction. RxList.com assumes no responsibility for any healthcare administered to a person based on the information found on this site.

As drug information can and will change at any time, RxList.com makes every effort to update its drug information. Due to the time-sensitive nature of drug information, RxList.com makes no guarantees that the information provided is the most current.

Any missing drug warnings or information does not in any way guarantee the safety, effectiveness, or the lack of adverse effects of any drug. The drug information provided is intended for reference only and should not be used as a substitute for medical advice.

If you have specific questions regarding a drug’s safety, side effects, usage, warnings, etc., you should contact your doctor or pharmacist, or refer to the individual drug monograph details found on the FDA.gov or RxList.com websites for more information.

You may also report negative side effects of prescription drugs to the FDA by visiting the FDA MedWatch website or calling 1-800-FDA-1088.


DailyMed. Aygestin Product Information.
DailyMed. Provera Product Information.

Health Solutions From Our Sponsors