Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 5/23/2022
Ayuna Side Effects Center

What Is Ayuna?

Ayuna (levonorgestrel and ethinyl estradiol tablets 0.15 mg/0.03 mg) is an oral contraceptive indicated for the prevention of pregnancy.

What Are Side Effects of Ayuna?

Common side effects of Ayuna include:

  • nausea,
  • vomiting,
  • abdominal pain,
  • cramps,
  • bloating,
  • breakthrough bleeding,
  • spotting,
  • changes in menstrual flow,
  • temporary infertility after discontinuation of treatment,
  • swelling/fluid retention,
  • freckles and skin discoloration,
  • breast changes (tenderness, pain, enlargement, secretion),
  • changes in weight or appetite,
  • vaginal discharge,
  • rash (allergic),
  • mood changes,
  • depression,
  • vaginal yeast infection, and
  • problems with contact lenses.

Serious side effects of Ayuna include blood clotting problems and other vascular problems, cancer of the reproductive organs, liver tumors, eye lesions, gallbladder disease, carbohydrate and lipid effects, elevated blood pressure, and headache.

Dosage for Ayuna

The dosage of Ayuna is one orange tablet daily for 21 consecutive days, followed by one green inert tablet daily for 7 consecutive days, according to prescribed schedule.

What Drugs, Substances, or Supplements Interact with Ayuna?

Ayuna may interact with primidone, phenylbutazone, drugs used for HIV, modafinil, antibiotics, lamotrigine, barbiturates, bosentan, carbamazepine, felbamate, griseofulvin, oxcarbazepine, phenytoin, rifampin, St. John's wort, and topiramate. Tell your doctor all medications and supplements you use.

Ayuna During Pregnancy or Breastfeeding

Ayuna is not recommended for use during pregnancy. Nursing mothers should be advised not to use combination oral contraceptives such as Ayuna but to use other forms of contraception until the child is completely weaned. Ayuna may reduce the quantity of breast milk produced. Consult your doctor before breastfeeding.

Additional Information

Our Ayuna (levonorgestrel and ethinyl estradiol tablets 0.15 mg/0.03 mg) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Which of the following are methods for contraception? See Answer
Ayuna Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using birth control pills and call your doctor at once if you have:

  • signs of a stroke--sudden numbness or weakness (especially on one side of the body), severe headache, slurred speech, balance problems;
  • signs of a blood clot--sudden vision loss, stabbing chest pain, feeling short of breath, coughing up blood, swelling or redness in an arm or leg;
  • heart attack symptoms--chest pain or pressure, pain spreading to your jaw or shoulder, nausea, sweating;
  • liver problems--loss of appetite, upper stomach pain, tiredness, fever, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • increased blood pressure--severe headache, blurred vision, pounding in your neck or ears;
  • swelling in your hands, ankles, or feet;
  • changes in the pattern or severity of migraine headaches;
  • a breast lump; or
  • symptoms of depression--sleep problems, weakness, tired feeling, mood changes.

Common side effects may include:

  • nausea, vomiting (especially when you first start taking this medicine);
  • breast tenderness;
  • breakthrough bleeding;
  • acne, darkening of facial skin;
  • weight gain; or
  • problems with contact lenses.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Ayuna (Levonorgestrel and Ethinyl Estradiol)


Choosing Your Birth Control Method See Slideshow
Ayuna Professional Information


An increased risk of the following serious adverse reactions (see WARNINGS section for additional information) has been associated with the use of oral contraceptives:

Thromboembolic disorders and other vascular problems (including thrombophlebitis, arterial thromboembolism, pulmonary embolism, myocardial infarction, cerebral hemorrhage, cerebral thrombosis), carcinoma of the reproductive organs, hepatic neoplasia (including hepatic adenomas or benign liver tumors), ocular lesions (including retinal vascular thrombosis), gallbladder disease, carbohydrate and lipid effects, elevated blood pressure, and headache.

The following adverse reactions have been reported in patients receiving oral contraceptives and are believed to be drug-related:

Gastrointestinal symptoms (such as abdominal pain, cramps and bloating)
Breakthrough bleeding
Change in menstrual flow
Temporary infertility after discontinuation of treatment
Edema/fluid retention
Melasma/chloasma which may persist
Breast changes: tenderness, pain, enlargement, secretion
Change in weight or appetite (increase or decrease)
Change in cervical erosion and secretion
Diminution in lactation when given immediately postpartum
Cholestatic jaundice
Rash (allergic)
Mood changes, including depression
Vaginitis, including candidiasis
Change in corneal curvature (steepening)
Intolerance to contact lenses
Mesenteric thrombosis
Decrease in serum folate levels
Exacerbation of systemic lupus erythematosus
Exacerbation of porphyria
Exacerbation of chorea
Aggravation of varicose veins

Anaphylactic/anaphylactoid reactions, including urticaria, angioedema, and severe reactions with respiratory and circulatory symptoms.

The following adverse reactions have been reported in users of oral contraceptives, and the association has been neither confirmed nor refuted:

Congenital anomalies
Premenstrual syndrome
Optic neuritis, which may lead to partial or complete loss of vision
Cystitis-like syndrome
Loss of scalp hair
Erythema multiforme
Erythema nodosum
Hemorrhagic eruption
Impaired renal function
Hemolytic uremic syndrome
Budd-Chiari syndrome
Changes in libido
Sickle-cell disease
Cerebral-vascular disease with mitral valve prolapse
Lupus-like syndromes

Read the entire FDA prescribing information for Ayuna (Levonorgestrel and Ethinyl Estradiol)

© Ayuna Patient Information is supplied by Cerner Multum, Inc. and Ayuna Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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