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Last reviewed on RxList: 4/11/2018
Ayuna Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

Last reviewed on RxList 4/11/2018

Ayuna (levonorgestrel and ethinyl estradiol tablets 0.15 mg/0.03 mg) is an oral contraceptive indicated for the prevention of pregnancy. Common side effects of Ayuna include:

  • nausea,
  • vomiting,
  • abdominal pain,
  • cramps,
  • bloating,
  • breakthrough bleeding,
  • spotting,
  • changes in menstrual flow,
  • temporary infertility after discontinuation of treatment,
  • swelling/fluid retention,
  • freckles and skin discoloration,
  • breast changes (tenderness, pain, enlargement, secretion),
  • changes in weight or appetite,
  • vaginal discharge,
  • rash (allergic),
  • mood changes,
  • depression,
  • vaginal yeast infection, and
  • problems with contact lenses.

Serious side effects of Ayuna include blood clotting problems and other vascular problems, cancer of the reproductive organs, liver tumors, eye lesions, gallbladder disease, carbohydrate and lipid effects, elevated blood pressure, and headache.

The dosage of Ayuna is one orange tablet daily for 21 consecutive days, followed by one green inert tablet daily for 7 consecutive days, according to prescribed schedule. Ayuna may interact with primidone, phenylbutazone, drugs used for HIV, modafinil, antibiotics, lamotrigine, barbiturates, bosentan, carbamazepine, felbamate, griseofulvin, oxcarbazepine, phenytoin, rifampin, St. John's wort, and topiramate. Tell your doctor all medications and supplements you use. Ayuna is not recommended for use during pregnancy. Nursing mothers should be advised not to use combination oral contraceptives such as Ayuna but to use other forms of contraception until the child is completely weaned. Ayuna may reduce the quantity of breast milk produced. Consult your doctor before breastfeeding.

Our Ayuna (levonorgestrel and ethinyl estradiol tablets 0.15 mg/0.03 mg) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Ayuna Professional Information


An increased risk of the following serious adverse reactions (see WARNINGS section for additional information) has been associated with the use of oral contraceptives:

Thromboembolic disorders and other vascular problems (including thrombophlebitis, arterial thromboembolism, pulmonary embolism, myocardial infarction, cerebral hemorrhage, cerebral thrombosis), carcinoma of the reproductive organs, hepatic neoplasia (including hepatic adenomas or benign liver tumors), ocular lesions (including retinal vascular thrombosis), gallbladder disease, carbohydrate and lipid effects, elevated blood pressure, and headache.

The following adverse reactions have been reported in patients receiving oral contraceptives and are believed to be drug-related:

Gastrointestinal symptoms (such as abdominal pain, cramps and bloating)
Breakthrough bleeding
Change in menstrual flow
Temporary infertility after discontinuation of treatment
Edema/fluid retention
Melasma/chloasma which may persist
Breast changes: tenderness, pain, enlargement, secretion
Change in weight or appetite (increase or decrease)
Change in cervical erosion and secretion
Diminution in lactation when given immediately postpartum
Cholestatic jaundice
Rash (allergic)
Mood changes, including depression
Vaginitis, including candidiasis
Change in corneal curvature (steepening)
Intolerance to contact lenses
Mesenteric thrombosis
Decrease in serum folate levels
Exacerbation of systemic lupus erythematosus
Exacerbation of porphyria
Exacerbation of chorea
Aggravation of varicose veins

Anaphylactic/anaphylactoid reactions, including urticaria, angioedema, and severe reactions with respiratory and circulatory symptoms.

The following adverse reactions have been reported in users of oral contraceptives, and the association has been neither confirmed nor refuted:

Congenital anomalies
Premenstrual syndrome
Optic neuritis, which may lead to partial or complete loss of vision
Cystitis-like syndrome
Loss of scalp hair
Erythema multiforme
Erythema nodosum
Hemorrhagic eruption
Impaired renal function
Hemolytic uremic syndrome
Budd-Chiari syndrome
Changes in libido
Sickle-cell disease
Cerebral-vascular disease with mitral valve prolapse
Lupus-like syndromes

Read the entire FDA prescribing information for Ayuna (Levonorgestrel and Ethinyl Estradiol)


Which of the following are methods for contraception? See Answer
Related Resources for Ayuna

© Ayuna Patient Information is supplied by Cerner Multum, Inc. and Ayuna Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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