Bactrim vs. Doxycycline Hyclate

Reviewed on 10/2/2019

Are Bactrim and Doxycycline Hyclate the Same Thing?

Bactrim (sulfamethoxazole and trimethoprim) and doxycycline are antibiotics used to treat different types of bacterial infections.

Brand names for doxycycline include Doxy-100, Oracea, Targadox, Vibramycin, Monodox, Oracea, and Adoxa.

Bactrim and doxycycline are different types of antibiotics. Bactrim is a combination of sulfonamide (a "sulfa" drug) and a folic acid inhibitor and doxycycline is a tetracycline antibiotic.

Side effects of Bactrim and doxycycline that are similar include nausea and vomiting.

Side effects of Bactrim that are different from doxycycline include loss of appetite, painful or swollen tongue, dizziness, spinning sensation, ringing in your ears, tiredness, and sleep problems (insomnia).

Side effects of doxycycline that are different from Bactrim include weight loss, diarrhea, rash, skin sensitivity to sunlight, hives, anemia, and vaginal yeast infection.

Both Bactrim and doxycycline may interact with seizure medications.

Bactrim may also interact with antidepressants, blood thinners, cyclosporine, oral diabetes medications, digoxin, diuretics (water pills), indomethacin, leucovorin, calcium folinate, methotrexate, and heart or blood pressure medications.

may also interact with anticoagulants, penicillin, antacids (containing aluminum, calcium, or magnesium), bismuth subsalicylate, iron-containing preparations, oral contraceptives, barbiturates, and methoxyflurane.

What Are Possible Side Effects of Bactrim?

Common side effects of Bactrim include:

  • loss of appetite,
  • nausea,
  • vomiting,
  • painful or swollen tongue,
  • dizziness,
  • spinning sensation,
  • ringing in your ears,
  • tiredness, or
  • sleep problems (insomnia).

Tell your doctor if you experience serious side effects of Bactrim including:

What Are Possible Side Effects of Doxycycline Hyclate?

Common side effects of Doxycycline Hyclate include:

  • weight loss
  • nausea
  • vomiting
  • diarrhea
  • rash
  • skin sensitivity to sunlight
  • hives
  • anemia, and
  • vaginal yeast infection

What is Bactrim?

Bactrim (sulfamethoxazole and trimethoprim) DS is a combination of two antibiotics used to treat urinary tract infections, acute otitis media, bronchitis, Shigellosis, Pneumocystis pneumonia, traveler's diarrhea, methicillin-resistant Staphylococcus aureus (MRSA), and other bacterial infections susceptible to this antibiotic. Bactrim is available as a generic drug.

What is Doxycycline Hyclate?

Doxycycline Hyclate Delayed-Release Tablets is a tetracycline-class antibiotic indicated for rickettsial infections, sexually transmitted infections, respiratory tract infections, specific bacterial infections, ophthalmic infections, anthrax (including inhalational anthrax, post-exposure), alternative treatment for selected infections when penicillin is contraindicated, adjunctive therapy in acute intestinal amebiasis and severe acne, and for prophylaxis of malaria. This medication is available in generic form.

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What Drugs Interact With Bactrim?

Bactrim may interact with blood thinners, cyclosporine, methotrexate, oral diabetes medications, and seizure medications.

Bactrim may also interact with antidepressants, digoxin, diuretics (water pills), indomethacin, leucovorin, calcium folinate, and heart or blood pressure medications.

What Drugs Interact With Doxycycline Hyclate?

Doxycycline hyclate may interact with anticoagulants, penicillin, antacids (containing aluminum, calcium, or magnesium), bismuth subsalicylate, iron-containing preparations, oral contraceptives, barbiturates, carbamazepine, phenytoin, and methoxyflurane. Tell your doctor all medications and supplements you use. Doxycycline hyclate is not recommended for use during pregnancy. Tetracycline-class drugs can cause fetal harm when administered to a pregnant woman. Doxycycline hyclate passes into breast milk.

How Should Bactrim Be Taken?

Administer the solution by intravenous infusion over a period of 60 to 90 minutes. Avoid administration by rapid infusion or bolus injection. Do NOT administer Bactrim intramuscularly.

How Should Doxycycline Hyclate Be Taken?

The usual adult dosage of doxycycline hyclate is 200 mg on the first day of treatment (administered 100 mg every 12 hours) followed by a maintenance dose of 100 mg daily. The pediatric dosage of doxycycline hyclate is based on the child's body weight.

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References
FDA. Bactrim Product Information.

https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/017377s068s073lbl.pdf

FDA. Doxycycline Hyclate Product Information.

https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=b333a1c0-1b70-4061-8a47-bca045f0cf28&type=display

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