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Bactroban Nasal

Last reviewed on RxList: 11/9/2020
Bactroban Nasal Side Effects Center

What Is Bactroban Nasal?

Bactroban Nasal (mupirocin calcium) Ointment, 2% is an antibiotic used to prevent severe staph infections in patients and healthcare workers who may be at risk of infection during an outbreak within a hospital or other healthcare setting.

What Are Side Effects of Bactroban Nasal?

Common side effects of Bactroban Nasal include

Tell your doctor if you experience serious side effects of Bactroban Nasal including nosebleed or severe burning or stinging of your nose.

Dosage for Bactroban Nasal

The dose of Bactroban Nasal for adults (12 years of age and older) is approximately one-half of the ointment from the single-use tube applied into 1 nostril and the other half into the other nostril twice daily (morning and evening) for 5 days, as directed.

What Drugs, Substances, or Supplements Interact with Bactroban Nasal?

Bactroban Nasal may interact with other drugs. Tell your doctor all medications and supplements you use.

Bactroban Nasal During Pregnancy and Breastfeeding

Bactroban Nasal should be used only when prescribed during pregnancy. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding

Additional Information

Our Bactroban Nasal (mupirocin calcium) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Bactroban Nasal Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives, skin rash; dizziness, fast or pounding heartbeats; wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody;
  • nosebleed; or
  • severe itching, rash, or other irritation in your nose.

Common side effects may include:

  • itching, burning, or stinging in your nose;
  • runny or stuffy nose;
  • altered sense of taste;
  • headache;
  • cough; or
  • sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Bactroban Nasal (Mupirocin Calcium Ointment)


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Bactroban Nasal Professional Information


The following adverse reactions are discussed in more detail in other sections of the labeling:

  • Systemic allergic reactions [see WARNINGS AND PRECAUTIONS]
  • Eye irritation [see WARNINGS AND PRECAUTIONS]
  • Local irritation [see WARNINGS AND PRECAUTIONS]
  • Clostridium difficile-associated diarrhea [see WARNINGS AND PRECAUTIONS]

Clinical Trials Experience

Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in practice.

In clinical trials, 210 domestic (US) and 2,130 foreign adult subjects received BACTROBAN nasal ointment. Less than 1% of domestic or foreign subjects in clinical trials were withdrawn due to adverse reactions.

The most frequently reported adverse reactions in foreign clinical trials were rhinitis (1%), taste perversion (0.8%), and pharyngitis (0.5%).

In domestic clinical trials, 17% (36 of 210) of adults treated with BACTROBAN nasal ointment reported adverse reactions thought to be at least possibly drug related. Table 1 shows the incidence of adverse reactions that were reported in at least 1% of adults enrolled in clinical trials conducted in the US.

Table 1: Adverse Reactions ( ≥ 1% Incidence) – Adults in US Trials

Adverse Reactions % of Subjects Experiencing Reactions BACTROBAN Nasal Ointment
(n = 210)
Headache 9%
Rhinitis 6%
Respiratory disorder, including upper respiratory tract congestion 5%
Pharyngitis 4%
Taste perversion 3%
Burning/stinging 2%
Cough 2%
Pruritus 1%

The following adverse reactions possibly drug related were reported in less than 1% of adults enrolled in domestic clinical trials: blepharitis, diarrhea, dry mouth, ear pain, epistaxis, nausea, and rash.

Postmarketing Experience

In addition to adverse reactions reported from clinical trials, the following reactions have been identified during postmarketing use of BACTROBAN nasal ointment. Because they are reported voluntarily from a population of unknown size, estimates of frequency cannot be made. These reactions have been chosen for inclusion due to a combination of their seriousness, frequency of reporting, or potential causal relationship to BACTROBAN nasal ointment.

Immune System Disorders

Systemic allergic reactions, including anaphylaxis, urticaria, angioedema, and generalized rash [see WARNINGS AND PRECAUTIONS].

Read the entire FDA prescribing information for Bactroban Nasal (Mupirocin Calcium Ointment)

Related Resources for Bactroban Nasal

Read the Bactroban Nasal User Reviews »

© Bactroban Nasal Patient Information is supplied by Cerner Multum, Inc. and Bactroban Nasal Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.


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