Benzamycin Side Effects Center

Last updated on RxList: 2/1/2022
Benzamycin Side Effects Center

What Is Benzamycin?

Benzamycin (erythromycin 3%-benzoyl peroxide 5%) Topical Gel is a combination of an antibiotic and a medication that has an antibacterial effect and a mild drying effect used to treat acne. Benzamycin is available in generic form.

What Are Side Effects of Benzamycin?

Common side effects of Benzamycin include:

  • skin dryness,
  • burning,
  • stinging,
  • tingling,
  • itching,
  • redness, and
  • peeling of the top layer of skin.

Skin irritation, itching, burning, or redness may occur, especially at the start of treatment as your body adjusts to Benzamycin. Other side effects of Benzamycin include:

  • eye irritation and
  • skin discoloration.

Serious side effects of Benzamycin are not likely to occur. Seek emergency medical attention if you experience an allergic reaction to Benzamycin (shortness of breath; closing of the throat; swelling of the lips, face, or tongue; or hives).

Dosage for Benzamycin

Apply a dose of Benzamycin Topical Gel twice daily, morning and evening, or as directed by a physician, to affected areas after the skin is thoroughly washed, rinsed with warm water and gently patted dry. Avoid using harsh, abrasive, or irritating cleansers, perfumes, or cosmetics on the area being treated. Do not use other topical prescription or over-the-counter products on the same area at the same time unless directed to do so by your doctor.

What Drugs, Substances, or Supplements Interact with Benzamycin?

Benzamycin may interact with tretinoin (Retin-A). Other drugs may interact with Benzamycin topical. Tell your doctor all medications you use.

Benzamycin During Pregnancy or Breastfeeding

During pregnancy, Benzamycin should be used only when prescribed. It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Benzamycin (erythromycin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Benzamycin Consumer Information

Benzoyl peroxide can cause a rare but serious allergic reaction or severe skin irritation. These reactions may occur just a few minutes after you apply the medicine, or within a day or longer afterward.

Stop using this medicine and get emergency medical help if you have any of these signs of an allergic reaction: hives, itching; difficult breathing, feeling light-headed; swelling of your face, lips, tongue, or throat.

Stop using this medicine and call your doctor at once if you have:

  • severe redness, burning, stinging, or peeling of treated skin areas; or
  • diarrhea that is watery or bloody.

Common side effects may include:

  • mild burning or stinging;
  • itching or tingly feeling;
  • dryness or peeling of treated skin; or
  • redness or other irritation.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Benzamycin (Erythromycin)


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Benzamycin Professional Information


In controlled clinical trials, the incidence of adverse reactions associated with the use of BENZAMYCIN (erythromycin) Topical Gel was approximately 3%. These were dryness and urticarial reaction.

The following additional local adverse reactions have been reported occasionally: irritation of the skin including peeling, itching, burning sensation, erythema, inflammation of the face, eyes and nose, and irritation of the eyes. Skin discoloration, oiliness and tenderness of the skin have also been reported.

Read the entire FDA prescribing information for Benzamycin (Erythromycin)

© Benzamycin Patient Information is supplied by Cerner Multum, Inc. and Benzamycin Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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