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Beta-Sitosterol

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Are there any interactions with medications?



Ezetimibe (Zetia)
Interaction Rating: Moderate Be cautious with this combination.
Talk with your health provider.

Taking ezetimibe (Zetia) can reduce of amount of beta-sitosterol the body absorbs. This might decrease the effectiveness of beta-sitosterol.



Pravastatin (Pravachol)
Interaction Rating: Minor Be cautious with this combination.
Talk with your health provider.

Taking pravastatin (Pravachol) might decrease how much beta-sitosterol is in the body. This might decrease the effectiveness of beta-sitosterol.

Dosing considerations for Beta-sitosterol.

The following doses have been studied in scientific research:

ADULTS

BY MOUTH:
  • For benign prostatic hyperplasia (BPH): 60-130 mg of beta-sitosterol divided into 2-3 doses daily has been used.
  • For high cholesterol: 0.65-1.5 grams of beta-sitosterol has been taken twice daily. Beta-sitosterol is usually taken along with a low-fat diet. A combination product containing 2.5 grams of beta-sitosterol and 8 grams of cholestyramine has also been taken daily for 12 weeks. Another combination product containing 8 grams of soy protein and 2 grams of beta-sitosterol has been used daily for 40 days.
  • For reducing cholesterol levels in adults with an inherited tendency toward high cholesterol (familial hypercholesterolemia): 2.5-21.1 grams of beta-sitosterol has been taken daily in divided doses, usually before meals. Some research suggests that beta-sitosterol is most effective when taken at a dose of 6 grams daily. Higher doses don't seem to work better.
CHILDREN

BY MOUTH:
  • For reducing cholesterol levels in children with an inherited tendency toward high cholesterol (familial hypercholesterolemia): 2-4 grams of beta-sitosterol taken 3 times daily for 3 months has been used in children and teenagers. Also 1 gram of beta-sitosterol has been taken 3 times daily in combination with the medication bezafibrate for 24 months.
Beta-sitosterol is usually taken along with a low-fat diet.


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