Betagan Side Effects Center

Last updated on RxList: 6/2/2021
Betagan Side Effects Center

What Is Betagan?

Betagan (levobunolol) ophthalmic solution is a beta-blocker that reduces pressure inside the eye used to treat open-angle glaucoma and other causes of high pressure inside the eye. Betagan is available in generic form.

What Are Side Effects of Betagan?

Common side effects of Betagan include:

  • temporary burning/stinging of the eye,
  • itchy/red eyes,
  • eye discomfort,
  • headache,
  • dizziness,
  • spinning sensation,
  • blurred vision,
  • swollen or puffy eyes,
  • depression,
  • confusion,
  • tiredness,
  • muscle weakness,
  • skin rash or itching,
  • nausea, or
  • diarrhea

Dosage for Betagan

The recommended starting dose is one to two drops of Betagan ophthalmic solution 0.5% in the affected eye(s) once a day. Typical dosing with Betagan is one to two drops twice daily.

What Drugs, Substances, or Supplements Interact with Betagan?

Betagan may interact with digoxin, reserpine, insulin or oral diabetes medications, other beta-blockers, calcium channel blockers, or medicines to treat psychiatric disorders. Tell your doctor all medications and supplements you use.

Betagan During Pregnancy or Breastfeeding

During pregnancy, Betagan should be used only when prescribed. It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Betagan (levobunolol) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Betagan Consumer Information

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Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Call your doctor at once if you have:

  • severe swelling, itching, burning, redness, pain, or discomfort in or around your eye;
  • bronchospasm (wheezing, chest tightness, trouble breathing);
  • a light-headed feeling, like you might pass out;
  • slow heart rate, weak pulse; or
  • numbness, cold feeling, or pale appearance of your fingers or toes.

Common side effects may include:

  • mild burning, stinging, or eye discomfort;
  • feeling like something is in your eye;
  • blurred vision;
  • dizziness, weakness;
  • headache; or
  • rash or itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Betagan Professional Information


In clinical trials the use of BETAGAN® ophthalmic solution has been associated with transient ocular burning and stinging in up to 1 in 3 patients, and with blepharoconjunctivitis in up to 1 in 20 patients. Decreases in heart rate and blood pressure have been reported (see CONTRAINDICATIONS and WARNINGS).

The following adverse reactions have been reported rarely with the use of BETAGAN® : iridocyclitis, headache, transient ataxia, dizziness, lethargy, urticaria, and pruritus.

Decreased corneal sensitivity has been noted in a small number of patients. Although levobunolol has minimal membrane-stabilizing activity, there remains a possibility of decreased corneal sensitivity after prolonged use.

The following additional adverse reactions have been reported either with BETAGAN® ophthalmic solution or ophthalmic use of other beta-adrenergic receptor blocking agents:

Body as a whole: Headache, asthenia, chest pain.

Cardiovascular: Bradycardia, arrhythmia, hypotension, syncope, heart block, cerebral vascular accident, cerebral ischemia, congestive heart failure, palpitation, cardiac arrest.

Digestive: Nausea, diarrhea.

Psychiatric: Depression, confusion, increase in signs and symptoms of myasthenia gravis, paresthesia.

Skin: Hypersensitivity, including localized and generalized rash, alopecia, Stevens-Johnson Syndrome.

Respiratory: Bronchospasm (predominantly in patients with pre-existing bronchospastic disease), respiratory failure, dyspnea, nasal congestion.

Urogenital: Impotence.

Endocrine: Masked symptoms of hypoglycemia in insulin-dependent diabetics (see WARNINGS).

Special Senses: Signs and symptoms of keratitis or eye allergy, blepharoptosis, visual disturbances including refractive changes (due to withdrawal of miotic therapy in some cases), diplopia, ptosis, and foreign body sensation in eye.

Other reactions associated with the oral use of non-selective adrenergic receptor blocking agents should be considered potential effects with ophthalmic use of these agents.

Read the entire FDA prescribing information for Betagan (Levobunolol)

© Betagan Patient Information is supplied by Cerner Multum, Inc. and Betagan Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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