Medical Author: John P. Cunha, DO, FACOEP Last updated on RxList: 10/25/2021
Betimol Side Effects Center

What Is Betimol?

Betimol (timolol) Ophthalmic Solution is a beta-blocker used to treat open-angle glaucoma and other causes of high pressure inside the eye.

What Are Side Effects of Betimol?

Common side effects of Betimol include blurred vision, double vision, drooping eyelids, swollen eyelids, burning or stinging in your eyes, dry eyes, itchy eyes, feeling like something is in your eye, eye redness, eye discomfort, headache, weakness, drowsiness, numbness, tingling, or cold feeling in your hands or feet, ringing in your ears, dry mouth, nausea, diarrhea, loss of appetite, upset stomach, skin rash or worsening psoriasis, sleep problems (insomnia), cough, or stuffy nose.

Dosage for Betimol

The usual starting dose is one drop of 0.25 percent Betimol in the affected eye(s) twice a day.

What Drugs, Substances, or Supplements Interact with Betimol?

Betimol may interact with clonidine, quinidine, reserpine, digitalis, acetazolamide, dichlorphenamide, methazolamide, oral timolol, other beta-blockers, calcium channel blockers, or antidepressants. Tell your doctor all medications and supplements you use.

Betimol During Pregnancy or Breastfeeding

During pregnancy, only use Betimol if prescribed. Betimol passes into breast milk and could harm a nursing baby. Consult your doctor before breastfeeding.

Additional Information

Our Betimol (timolol) Ophthalmic Solution Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Betimol Consumer Information

Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Although the risk of serious side effects is low when timolol is used in the eyes, side effects can occur if the medicine is absorbed into your bloodstream. Call your doctor right away if you have:

  • wheezing, chest pain, trouble breathing, slow heartbeats;
  • a light-headed feeling, like you might pass out;
  • muscle weakness;
  • depressed mood, confusion, hallucinations, unusual thoughts or behavior; or
  • numbness or cold feeling in your hands and feet.

Also call your doctor if you have:

  • severe stinging or burning after using the eye drops:
  • eye swelling, redness, severe discomfort, crusting or drainage (may be signs of infection); or
  • blurred vision, tunnel vision, eye pain, or seeing halos around lights.

Common side effects may include:

  • burning or stinging in your eye;
  • dry eyes, itching;
  • feeling like something is in your eye;
  • red or puffy eyelids; or
  • headache.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Betimol (Timolol Ophthalmic Solution)


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Betimol Professional Information


The most frequently reported ocular event in clinical trials was burning/stinging on instillation and was comparable between Betimol* and timolol maleate (approximately one in eight patients).

The following adverse events were associated with use of Betimol® in frequencies of more than 5% in two controlled, double masked clinical studies in which 184 patients received 0.25% or 0.5% Betimol:

OCULAR: Dry eyes, itching, foreign body sensation, discomfort in the eye, eyelid erythema, conjunctival injection, and headache.

BODY AS A WHOLE: Headache.

The following side effects were reported in frequencies of 1 to 5%:

OCULAR: Eye pain, epiphora, photophobia, blurred or abnormal vision, corneal fluorescein staining, keratitis, blepharitis and cataract.

BODY AS A WHOLE: Allergic reaction, asthenia, common cold and pain in extremities.




NERVOUS SYSTEM/PSYCHIATRY: Dizziness and dry mouth.

RESPIRATORY: Respiratory infection and sinusitis.

In addition, the following adverse reactions have been reported with ophthalmic use of beta blockers:

OCULAR: Conjunctivitis, blepharoptosis, decreased corneal sensitivity, visual disturbances including refractive changes, diplopia and retinal vascular disorder.

BODY AS A WHOLE: Chest pain.

CARDIOVASCULAR: Arrhythmia, palpitation, bradycardia, hypotension, syncope, heart block, cerebral vascular accident, cerebral ischemia, cardiac failure and cardiac arrest.

DIGESTIVE: Diarrhea.

ENDOCRINE: Masked symptoms of hypoglycemia in insulin dependent diabetics (See WARNINGS).

NERVOUS SYSTEM/PSYCHIATRY: Depression, impotence, increase in signs and symptoms of myasthenia gravis and paresthesia.

RESPIRATORY: Dyspnea, bronchospasm, respiratory failure and nasal congestion.

SKIN: Alopecia, hypersensitivity including localized and generalized rash, urticaria.

Read the entire FDA prescribing information for Betimol (Timolol Ophthalmic Solution)

© Betimol Patient Information is supplied by Cerner Multum, Inc. and Betimol Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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