Bicillin C-R Side Effects Center

Last updated on RxList: 11/7/2022
Bicillin C-R Side Effects Center

What Is Bicillin C-R?

Bicillin C-R (penicillin G benzathine and penicillin G procaine) Injectable Suspension is an antibiotic used to treat many different types of severe infections, including strep and staph infections, diphtheria, meningitis, gonorrhea, and syphilis. Bicillin C-R is also used to prevent infections of the heart valves in people with certain heart conditions who need to have dental work or surgery.

What Are Side Effects of Bicillin C-R?

Bicillin C-R may cause serious side effects including:

  • hives,
  • difficulty breathing,
  • swelling of your face, lips, tongue, or throat,
  • joint pain,
  • chills,
  • pain, numbness, tingling, burning, or feeling cold,
  • pale or mottled skin,
  • blue-colored lips, fingers, or toes,
  • severe pain, tingling, weakness, or swelling in your lower leg,
  • weakness in your arms or legs,
  • blistering, peeling, discoloration, or painful skin changes, where the medicine was injected,
  • severe stomach pain,
  • diarrhea that is watery or bloody (even if it occurs months after last dose),
  • lightheadedness,
  • slow heart rate,
  • weak pulse,
  • fainting,
  • slow breathing,
  • pounding heartbeats,
  • fluttering in your chest,
  • confusion,
  • agitation,
  • hallucinations,
  • extreme fear,
  • seizure,
  • warmth, redness, bleeding, a lump, or skin changes where the medicine was injected,
  • easy bruising or bleeding,
  • pale or yellowed skin,
  • dark colored urine,
  • urination problems,
  • fever,
  • chills,
  • mouth sores,
  • warmth or redness under your skin, and,
  • vaginal itching or discharge

Get medical help right away, if you have any of the symptoms listed above.

Common side effects of Bicillin C-R include:

  • injection site reactions (pain, swelling, bruising, skin changes, or a hard lump),
  • nausea,
  • vomiting,
  • blurred vision,
  • ringing in your ears,
  • headache,
  • dizziness, or
  • skin rash.

Tell your doctor if you have serious side effects of Bicillin C-R including:

  • severe pain or peeling skin at injection site,
  • joint or muscle pain,
  • shortness of breath,
  • dizziness,
  • vision changes,
  • fast/slow/pounding heartbeat,
  • numbness or tingling of arms or legs,
  • pain/redness/swelling of arms or legs,
  • change in skin color near injection site or on arms or legs,
  • uncontrolled movements,
  • inability to move,
  • change in the amount of urine,
  • new signs of infection (e.g., fever, persistent sore throat),
  • easy bruising or bleeding,
  • extreme tiredness,
  • dark or cloudy urine,
  • seizures, or
  • mental/mood changes (e.g., depression, agitation).

Seek medical care or call 911 at once if you have the following serious side effects:

  • Serious eye symptoms such as sudden vision loss, blurred vision, tunnel vision, eye pain or swelling, or seeing halos around lights;
  • Serious heart symptoms such as fast, irregular, or pounding heartbeats; fluttering in your chest; shortness of breath; and sudden dizziness, lightheadedness, or passing out;
  • Severe headache, confusion, slurred speech, arm or leg weakness, trouble walking, loss of coordination, feeling unsteady, very stiff muscles, high fever, profuse sweating, or tremors.

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

Dosage for Bicillin C-R

Bicillin C-R is given by injection under physician supervision. Dose of Bicillin C-R is is determined by the type of infection, the patient's age, weight, and response to treatment.

What Drugs, Substances, or Supplements Interact with Bicillin C-R?

Bicillin C-R may interact with probenecid, blood thinners, methotrexate, or tetracycline antibiotics. Tell your doctor all medications and supplements you use.

Bicillin C-R During Pregnancy or Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant during treatment with Bicillin C-R; it is not expected to be harmful to a fetus. Bicillin C-R passes into breast milk. Consult your doctor before breastfeeding.

Additional Information

Our Bicillin C-R (penicillin G benzathine and penicillin G procaine) Injectable Suspension Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

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Bicillin C-R Consumer Information

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Get emergency medical help if you have signs of an allergic reaction (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Some side effects may occur if the medicine has been accidentally injected near a vein or nerve. Tell your caregivers right away if you feel light-headed or if you have:

  • slow heart rate, weak pulse, slow breathing (breathing may stop);
  • pain, numbness, tingling, burning, or feeling cold;
  • pale or mottled skin, blue-colored lips, fingers, or toes;
  • severe pain or swelling in your lower leg;
  • weakness in your arms or legs; or
  • blistering, peeling, discoloration, or painful skin changes where the medicine was injected.

Also call your doctor at once if you have:

  • severe stomach pain, diarrhea that is watery or bloody (even if it occurs months after your last dose);
  • confusion, agitation, hallucinations (seeing or hearing things that are not real), extreme fear;
  • a seizure;
  • pain, swelling, warmth, redness, bruising, bleeding, or a lump where the medicine was injected;
  • pale or yellowed skin, bruising or bleeding, dark colored urine;
  • urination problems; or
  • signs of a new infection--fever, chills, mouth sores, vaginal itching or discharge.

Seek medical attention right away if you develop a serious condition called methemoglobinemia. Symptoms include headache, fast heartbeats, shortness of breath, feeling tired or light-headed, or skin that looks pale, gray, or blue-colored.

Common side effects may include:

  • nausea, vomiting, diarrhea;
  • itching, sweating, allergic reaction;
  • flushing (sudden warmth, redness, or tingly feeling);
  • feeling anxious or nervous;
  • headache, dizziness, drowsiness; or
  • pain, swelling, or bruising where an injection was given.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

QUESTION

Bowel regularity means a bowel movement every day. See Answer
Bicillin C-R Professional Information

SIDE EFFECTS

As with other penicillins, untoward reactions of the sensitivity phenomena are likely to occur, particularly in individuals who have previously demonstrated hypersensitivity to penicillins or in those with a history of allergy, asthma, hay fever, or urticaria.

The following have been reported with parenteral penicillin G:

General: Hypersensitivity reactions including the following: skin eruptions (maculopapular to exfoliative dermatitis), urticaria, laryngeal edema, fever, eosinophilia; other serum sickness-like reactions (including chills, fever, edema, arthralgia, and prostration); and anaphylaxis including shock and death. Note: Urticaria, other skin rashes, and serum sickness-like reactions may be controlled with antihistamines and, if necessary, systemic corticosteroids. Whenever such reactions occur, penicillin G should be discontinued unless, in the opinion of the physician, the condition being treated is life-threatening and amenable only to therapy with penicillin G. Serious anaphylactic reactions require immediate emergency treatment with epinephrine. Oxygen, intravenous steroids, and airway management, including intubation, should also be administered as indicated.

Gastrointestinal: Pseudomembranous colitis. Onset of pseudomembranous colitis symptoms may occur during or after antibacterial treatment. (See WARNINGS section.)

Hematologic: Hemolytic anemia, leukopenia, thrombocytopenia.

Neurologic: Neuropathy.

Urogenital: Nephropathy.

The following adverse events have been temporally associated with parenteral administrations of penicillin G benzathine:

Body as a Whole: Hypersensitivity reactions including allergic vasculitis, pruritis, fatigue, asthenia, and pain; aggravation of existing disorder; headache.

Cardiovascular: Cardiac arrest; hypotension; tachycardia; palpitations; pulmonary hypertension; pulmonary embolism; vasodilation; vasovagal reaction; cerebrovascular accident; syncope.

Gastrointestinal: Nausea, vomiting; blood in stool; intestinal necrosis.

Hemic and Lymphatic: Lymphadenopathy.

Injection Site: Injection site reactions including pain, inflammation, lump, abscess, necrosis, edema, hemorrhage, cellulitis, hypersensitivity, atrophy, ecchymosis, and skin ulcer. Neurovascular reactions including warmth, vasospasm, pallor, mottling, gangrene, numbness of the extremities, cyanosis of the extremities, and neurovascular damage.

Metabolic: Elevated BUN, creatinine, and SGOT.

Musculoskeletal: Joint disorder, periostitis; exacerbation of arthritis; myoglobinuria; rhabdomyolysis.

Nervous System: Nervousness; tremors; dizziness; somnolence; confusion; anxiety; euphoria; transverse myelitis; seizures; coma. A syndrome manifested by a variety of CNS symptoms such as severe agitation with confusion, visual and auditory hallucinations, and a fear of impending death (Hoigne’s syndrome), has been reported after administration of penicillin G procaine and, less commonly, after injection of the combination of penicillin G benzathine and penicillin G procaine. Other symptoms associated with this syndrome, such as psychosis, seizures, dizziness, tinnitus, cyanosis, palpitations, tachycardia, and/or abnormal perception in taste, also may occur.

Respiratory: Hypoxia; apnea; dyspnea.

Skin: Diaphoresis.

Special Senses: Blurred vision; blindness.

Urogenital: Neurogenic bladder; hematuria; proteinuria; renal failure; impotence; priapism.

Read the entire FDA prescribing information for Bicillin C-R (Penicillin G Benzathine and Penicillin G Procaine Inj)

© Bicillin C-R Patient Information is supplied by Cerner Multum, Inc. and Bicillin C-R Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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